Browsing Ciències Bàsiques by Issue Date
Now showing items 21-40 of 65
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ADP-ribose–derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling
(Science, 2016)Key nuclear processes in eukaryotes, including DNA replication, repair, and gene regulation, require extensive chromatin remodeling catalyzed by energy-consuming enzymes. It remains unclear how the ATP ... -
Hormone-induced repression of genes requires BRG1-mediated H1.2 deposition at target promoters
(The EMBO Journal, 2016)Eukaryotic gene regulation is associated with changes in chromatin compaction that modulate access to DNA regulatory sequences relevant for transcriptional activation or repression. Although much is ... -
Simplified qualitative discrete numerical model to determine cracking pattern in brittle materials by means of finite element method
(Mathematical Problems in Engineering, 2017)This paper presents the formulation, implementation, and validation of a simplified qualitative model to determine the crack path of solids considering static loads, infinitesimal strain, and plane ... -
Functional characterization of a novel non-coding mutation “Ghent +49A > G” in the iron-responsive element of L-ferritin causing hereditary hyperferritinaemia-cataract syndrome
(Scientific Reports, 2017)Hereditary hyperferritinaemia-cataract syndrome (HHCS) is a rare disorder usually caused by heterozygous mutations in the iron-responsive element (IRE) in the 5′ untranslated region (5′UTR) of the ... -
Derivation of nearest-neighbor DNA parameters in magnesium from single molecule experiments
(Nucleic Acids Research, 2017)DNA hybridization is an essential molecular reaction in biology with many applications. The nearest-neighbor (NN) model for nucleic acids predicts DNA thermodynamics using energy values for the different ... -
Evolutionary footprints reveal insights into plant MicroRNA biogenesis
(The Plant Cell, 2017)MicroRNAs (miRNAs) are endogenous small RNAs that recognize target sequences by base complementarity and play a role in the regulation of target gene expression. They are processed from longer precursor ... -
Spatial control of gene expression by miR319-regulated TCP transcription factors in leaf development
(Plant Physiology, 2018)The characteristic leaf shapes we see in all plants are in good part the outcome of the combined action of several transcription factor networks that translate into cell division activity during the ... -
Unliganded progesterone receptor governs estrogen receptor gene expression by regulating DNA methylation in breast cancer cells
(Cancers, 2018)Breast cancer prognosis and response to endocrine therapy strongly depends on the expression of the estrogen and progesterone receptors (ER and PR, respectively). Although much is known about ERα gene ... -
A simplified scheme for piezoelectric anisotropic analysis in human vertebrae using integral methods
(Mathematical Problems in Engineering, 2018)This paper outlines a computational model for the analysis of the piezoelectric behaviour of the vertebral body remodelling process. Particular attention is paid to the algorithms for the simulation of ... -
Efficiency and precision of microRNA biogenesis modes in plants
(Nucleic Acids Research, 2018)Many evolutionarily conserved microRNAs (miRNAs) in plants regulate transcription factors with key functions in development. Hence, mutations in the core components of the miRNA biogenesis machinery ... -
Regulation of actin dynamics during structural plasticity of dendritic spines: signaling messengers and actin-binding proteins
(Molecular and Cellular Neuroscience, 2018-09)Activity-dependent plasticity of synaptic structure and function plays an essential role in neuronal development and in cognitive functions including learning and memory. The formation, maintenance and ... -
Rationally designed azobenzene photoswitches for efficient two-photon neuronal excitation
(Nature Communications, 2019)Manipulation of neuronal activity using two-photon excitation of azobenzene photoswitches with near-infrared light has been recently demonstrated, but their practical use in neuronal tissue to photostimulate ... -
Improved dynamical particle swarm optimization method for structural dynamics
(Mathematical Problems in Engineering, 2019)A methodology to the multiobjective structural design of buildings based on an improved particle swarm optimization algorithm is presented, which has proved to be very efficient and robust in nonlinear ... -
ATP, Mg2+, nuclear phase separation, and genome accessibility
(Trends in Biochemical Sciences, 2019)Misregulation of the processes controlling eukaryotic gene expression can result in disease. Gene expression is influenced by the surrounding chromatin; hence the nuclear environment is also of vital ... -
Identification of key sequence features required for microRNA biogenesis in plants
(Nature Communications, 2020)MicroRNAs (miRNAs) are endogenous small RNAs of ∼21 nt that regulate multiple biological pathways in multicellular organisms. They derive from longer transcripts that harbor an imperfect stem-loop ... -
MetaPhOrs 2.0: integrative, phylogeny-based inference of orthology and paralogy across the tree of life
(Nucleic Acids Research, 2020)Inferring homology relationships across genes in different species is a central task in comparative genomics. Therefore, a large number of resources and methods have been developed over the years. Some ... -
Engineering a genome-reduced bacterium to eliminate Staphylococcus aureus biofilms in vivo
(Molecular Systems Biology, 2021)Bacteria present a promising delivery system for treating human diseases. Here, we engineered the genome-reduced human lung pathogen Mycoplasma pneumoniae as a live biotherapeutic to treat biofilm-associated ... -
Assessing the potential role of copper and cobalt in stimulating angiogenesis for tissue regeneration
(PLoS One, 2021)The use of copper (Cu2+) and cobalt (Co2+) has been described to stimulate blood vessel formation, a key process for the success of tissue regeneration. However, understanding how different concentrations ... -
Structural characterization of NORAD reveals a stabilizing role of spacers and two new repeat units
(Computational and Structural Biotechnology Journal, 2021)Long non-coding RNAs (lncRNAs) can perform a variety of key cellular functions by interacting with proteins and other RNAs. Recent studies have shown that the functions of lncRNAS are largely mediated ... -
LoxTnSeq: random transposon insertions combined with cre/lox recombination and counterselection to generate large random genome reductions
(Microbial Biotechnology, 2021)The removal of unwanted genetic material is a key aspect in many synthetic biology efforts and often requires preliminary knowledge of which genomic regions are dispensable. Typically, these efforts are ...