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Engineering a genome reduced bacterium to eliminate Staphylococcus aureus biofilms in vivo
(Molecular Systems Biology, 2021)Bacteria present a promising delivery system for treating human diseases. Here, we engineered the genome-reduced human lung pathogen Mycoplasma pneumoniae as a live biotherapeutic to treat biofilm-associated ... -
Modeling cell adhesion and proliferation: a cellular-automata based approach
(Advanced Modeling and Simulation in Engineering Sciences, 2015)Background: Cell adhesion is a process that involves the interaction between the cell membrane and another surface, either a cell or a substrate. Unlike experimental tests, computer models can simulate ... -
Influence of bone-level dental implants placement and of cortical thickness on osseointegration: in silico and in vivo analyses
(Journal of Clinical Medicine, 2022)The purpose of this research is to study the biomechanical response of dental implants in bone-level type locations, 0.5 mm above and below the bone level. In addition, the influence of the thickness ... -
A simplified scheme for piezoelectric anisotropic analysis in human vertebrae using integral methods
(Mathematical Problems in Engineering, 2018)This paper outlines a computational model for the analysis of the piezoelectric behaviour of the vertebral body remodelling process. Particular attention is paid to the algorithms for the simulation of ... -
Simplified qualitative discrete numerical model to determine cracking pattern in brittle materials by means of finite element method
(Mathematical Problems in Engineering, 2017)This paper presents the formulation, implementation, and validation of a simplified qualitative model to determine the crack path of solids considering static loads, infinitesimal strain, and plane ... -
Improved dynamical particle swarm optimization method for structural dynamics
(Mathematical Problems in Engineering, 2019)A methodology to the multiobjective structural design of buildings based on an improved particle swarm optimization algorithm is presented, which has proved to be very efficient and robust in nonlinear ... -
Application of percutaneous needle electrolysis does not elicit temperature changes: an in vitro cadaveric study
(International Journal of Environmental Reseacrh and Public Health, 2022)Percutaneous needle electrolysis (PNE) consists of the ultrasound-guided application of a galvanic electrical current through a solid filament needle. One proposed therapeutic mechanism for this ... -
The ADP-ribose hydrolase NUDT5 is important for DNA repair
(Cell Reports, 2022-12)DNA damage leads to rapid synthesis of poly(ADP-ribose) (pADPr), which is important for damage signaling and repair. pADPr chains are removed by poly(ADP-ribose) glycohydrolase (PARG), releasing free ... -
Engineered live bacteria suppress Pseudomonas aeruginosa infection in mouse lung and dissolve endotracheal-tube biofilms
(Nature Biotechnology, 2023)Engineered live bacteria could provide a new modality for treating lung infections, a major cause of mortality worldwide. In the present study, we engineered a genome-reduced human lung bacterium, ... -
Rationally designed azobenzene photoswitches for efficient two-photon neuronal excitation
(Nature Communications, 2019)Manipulation of neuronal activity using two-photon excitation of azobenzene photoswitches with near-infrared light has been recently demonstrated, but their practical use in neuronal tissue to photostimulate ... -
Regulation of actin dynamics during structural plasticity of dendritic spines: signaling messengers and actin-binding proteins
(Molecular and Cellular Neuroscience, 2018-09)Activity-dependent plasticity of synaptic structure and function plays an essential role in neuronal development and in cognitive functions including learning and memory. The formation, maintenance and ... -
Effectiveness of a multicomponent training program on physical performance and muscle quality in older adults: a quasi-experimental study
(International Journal of Environmental Research and Public Health, 2023)Aging is associated with a decrease in functional capacity, manifested by a loss of strength, physical performance and muscle quality. Multicomponent training (MCT), characterized by the combination of ... -
Study on balance and postural control sccording to the stabilometry in indoor skydivers: a cross-sectional study
(International Journal of Environmental Research and Public Health, 2023)Background: The wind tunnel is a compression cabin through which a stream of air rises homogeneously, generated by fans. To perform different acrobatics, indoor skydivers have to change their body ... -
SURE editing: combining oligo-recombineering and programmable insertion/deletion of selection markers to efficiently edit the Mycoplasma pneumoniae genome
(Nucleic Acids Research, 2022)The development of advanced genetic tools is boosting microbial engineering which can potentially tackle wide-ranging challenges currently faced by our society. Here we present SURE editing, a ... -
Global signalling network analysis of luminal T47D breast cancer cells in response to progesterone
(Frontiers in Endocrinology, 2022)Background: Breast cancer cells enter into the cell cycle following progestin exposure by the activation of signalling cascades involving a plethora of enzymes, transcription factors and co-factors that ... -
Correlation between physical performance and stabilometric parameters in older adults
(Medicina, 2022)Background and Objectives: Falls are a common and serious threat to the health and independence of older adults. The decrease in functional capacity during aging means an increased risk of falls. To ... -
Interexaminer reliability and validity of quantity of cervical mobility during online dynamic inspection
(Diagnostics, 2022)Background: Physical therapists routinely measure range of motion (ROM) of cervical spine. The reliability of the cervical range of motion (CROM) device has been demonstrated in several studies, but ... -
ADP-ribose–derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling
(Science, 2016)Key nuclear processes in eukaryotes, including DNA replication, repair, and gene regulation, require extensive chromatin remodeling catalyzed by energy-consuming enzymes. It remains unclear how the ATP ... -
Hormone-induced repression of genes requires BRG1-mediated H1.2 deposition at target promoters
(The EMBO Journal, 2016)Eukaryotic gene regulation is associated with changes in chromatin compaction that modulate access to DNA regulatory sequences relevant for transcriptional activation or repression. Although much is ... -
Unliganded progesterone receptor governs estrogen receptor gene expression by regulating DNA methylation in breast cancer cells
(Cancers, 2018)Breast cancer prognosis and response to endocrine therapy strongly depends on the expression of the estrogen and progesterone receptors (ER and PR, respectively). Although much is known about ERα gene ...