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Advanced Binary Guanosine and Guanosine 5'-Monophosphate Cell-Laden Hydrogels for Soft Tissue Reconstruction by 3D Bioprinting
(ACS Applied Materials & Interfaces, 2023)Softtissue defects or pathologies frequently necessitate the useof biomaterials that provide the volume required for subsequent vascularizationand tissue formation as autrografts are not always a feasible ... -
Developing a pure silica ink for 3D printing through sol-gel reaction and mild conditions
(Journal of Sol-Gel Science and Technology, 2023)Silica 3D printable materials are interesting in bone tissue engineering as they allow the development of custom-made scaffolds with high bioactivity and osteogenic properties. However, all pure silica ... -
Rel/NF-κB Transcription Factors Emerged at the Onset of Opisthokonts
(Genome Biology and Evolution, 2022)The Rel/NF-kappa B transcription factor family has myriad roles in immunity, development, and differentiation in animals, and was considered a key innovation for animal multicellularity. Rel homology ... -
Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri
(BMC Biology, 2021)Background The opportunistic pathogen Naegleria fowleri establishes infection in the human brain, killing almost invariably within 2 weeks. The amoeba performs piece-meal ingestion, or trogocytosis, of ... -
Stable transfection in protist Corallochytrium limacisporum identifies novel cellular features among unicellular animals relatives
(Current Biology, 2021)The evolutionary path from protists to multicellular animals remains a mystery. Recent work on the genomes of several unicellular relatives of animals has shaped our understanding of the genetic changes ... -
Genetic tool development in marine protists: emerging model organisms for experimental cell biology
(Nature Methods, 2020)Diverse microbial ecosystems underpin life in the sea. Among these microbes are many unicellular eukaryotes that span the diversity of the eukaryotic tree of life. However, genetic tractability has ... -
Genome-wide Transcriptional Analysis of Tetrahymena thermophila Response to Exogenous Cholesterol
(Journal of Eukaryotic Microbiology, 2019)The ciliate Tetrahymena thermophila does not require sterols for growth and synthesizes pentacyclic triterpenoid alcohols, mainly tetrahymanol, as sterol surrogates. However, when sterols are present ... -
Reticulate evolution in eukaryotes: Origin and evolution of the nitrate assimilation pathway
(PLOS Genetics, 2019)Genes and genomes can evolve through interchanging genetic material, this leading to reticular evolutionary patterns. However, the importance of reticulate evolution in eukaryotes, and in particular of ... -
Novel Diversity of Deeply Branching Holomycota and Unicellular Holozoans Revealed by Metabarcoding in Middle Parana River, Argentina
(Frontiers in Ecology and Evolution, 2018)Opisthokonta represents a major lineage of eukaryotes and includes fungi and metazoans, as well as other less known unicellular groups. The latter are paraphyletic assemblages that branch in between the ... -
Transfection of Capsaspora owczarzaki, a close unicellular relative of animals
(Development, 2018)How animals emerged from their unicellular ancestor remains a major evolutionary question. New genome data from the closest unicellular relatives of animals have provided important insights into the ... -
Sterol metabolism in the filasterean Capsaspora owczarzaki has features that resemble both fungi and animals
(Open Biology, 2016)Sterols are essential for several physiological processes in most eukaryotes. Sterols regulate membrane homeostasis and participate in different signalling pathways not only as precursors of steroid ... -
The Sterol-C7 Desaturase from the Ciliate Tetrahymena thermophila Is a Rieske Oxygenase, Which Is Highly Conserved in Animals
(Molecular Biology and Evolution, 2013)The ciliate Tetrahymena thermophila incorporates sterols from its environment that desaturates at positions C5(6), C7(8), and C22(23). Phytosterols are additionally modified by removal of the ethyl group ... -
A novel sterol desaturase-like protein promoting dealkylation of phytosterols in Tetrahymena thermophila
(Eukaryotic Cell, 2011)The gene TTHERM_00438800 (DES24) from the ciliate Tetrahymena thermophila encodes a protein with three conserved histidine clusters, typical of the fatty acid hydroxylase superfamily. Despite its high ... -
C5(6) sterol desaturase from Tetrahymena thermophila: gene identification and knockout, sequence analysis and comparison to other C5(6) sterol desaturases
(Eukaryotic Cell, 2009)The gene coding for a C-5(6) sterol desaturase in Tetrahymena thermophila, DES5A, has been identified by the knockout of the TTHERM_01194720 sequence. Macronucleus transformation was achieved by biolistic ... -
Oligomerization of Bacillus subtilis DesR is required for fine tuning regulation of membrane fluidity
(Biochimica et Biophysica Acta (BBA) - General Subjects, 2009)The DesK-DesR two-component system regulates the order of membrane lipids in the bacterium Bacillus subtilis by controlling the expression of the des gene coding for the delta 5-acyl-lipid desaturase. ... -
Arithmetic and k-maximality of the cyclic free magma
(Algebra universalis, 2019)We survey free magmas and we explore the structure of their submagmas. By equipping the cyclic free magma with a second distributive operation we obtain a ringoid-like structure with some primitive ... -
Equidecomposable magmas
(Algebra universalis, 2020)A magma is called equidecomposable when the operation is injective, or, in other words, if x+y=x′+y′ implies that x=x′ and y=y′. A magma is free iff it is equidecomposable and graded, hence the notion ... -
Anti-context-free languages
(Journal of Automata, Languages and Combinatorics, 2023)Context-free languages can be characterized in several ways. This article studies projective linearisations of languages of simple dependency trees, i. e., dependency trees in which a node can govern ... -
Growth and density in free magmas
(Journal of Algebraic Combinatorics, 2025-07-15)Free magmas are graded by a length function. The growth of a submagma is the sequence of the ball sizes using the length as a norm. Given a pair of submagmas N and M, with , of a free magma, we define ... -
A note on the probability of a groupoid having deficient sets
(Algebra universalis, 2025-09-22)A subset X of a groupoid is said to be deficient if |X \cdot X|\leq |X|. It is well-known that the probability that a random groupoid has a deficient t-element set with t\geq 3 is zero. However, as ...