Enviaments recents 

Ciències de la Salut: Enviaments recents

Ara mostrant els elements 961-980 de 1006

    • Competition in the chaperone-client network subordinates cell-cycle entry to growth and stress 

      Moreno, David F.; Parisi, Eva; Yahya, Galal; Vaggi, Federico; Csikász-Nagy, Attila; Aldea Malo, Martí (Life Science Alliance, 2019-04-15)
      The precise coordination of growth and proliferation has a universal prevalence in cell homeostasis. As a prominent property, cell size is modulated by the coordination between these processes in ...

    • Centromeric signaling proteins boost G1 cyclin degradation and modulate cell size in budding yeast 

      Martínez-Láinez, Joan M.; Moreno, David F.; Parisi, Eva; Clotet Erra, Josep; Aldea Malo, Martí (PLoS Biology, 2018-08-06)
      Cell size scales with ploidy in a great range of eukaryotes, but the underlying mechanisms remain unknown. Using various orthogonal single-cell approaches, we show that cell size increases linearly ...

    • Growth rate as a direct regulator of the start network to set cell size 

      Aldea Malo, Martí; Jenkins, Kirsten; Csikász-Nagy, Attila (Frontiers in Cell and Developmental Biology, 2017-05-26)
      Cells are able to adjust their growth and size to external inputs to comply with specific fates and developmental programs. Molecular pathways controlling growth also have an enormous impact in cell ...

    • Nucleosome architecture throughout the cell cycle 

      Deniz, Özgen; Flores, Óscar; Aldea Malo, Martí; Soler-López, Montserrat; Orozco, Modesto (Scientific Reports, 2016-01-28)
      Nucleosomes provide additional regulatory mechanisms to transcription and DNA replication by mediating the access of proteins to DNA. During the cell cycle chromatin undergoes several conformational ...

    • The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation 

      Ferrezuelo, Francisco; Colomina, Neus; Palmisano, Alida; Garí, Eloi; Gallego, Carme; Csikász-Nagy, Attila; Aldea Malo, Martí (Nature Communications, 2012-08-21)
      Budding yeast cells are assumed to trigger Start and enter the cell cycle only after they attain a critical size set by external conditions. However, arguing against deterministic models of cell size ...

    • The transcriptional network activated by Cln3 cyclin at the G1-to-S transition of the yeast cell cycle 

      Ferrezuelo, Francisco; Colomina, Neus; Futcher, Bruce; Aldea Malo, Martí (Genome Biology, 2010-06-23)
      Background: The G1-to-S transition of the cell cycle in the yeast Saccharomyces cerevisiae involves an extensive transcriptional program driven by transcription factors SBF (Swi4-Swi6) and MBF (Mbp1-Swi6). ...

    • Polymeric additives to enhance the functional properties of calcium phosphate cements 

      Pérez Antoñanzas, Roman; Hae-Won, Kim; Ginebra Molins, Maria Pau (2012-03-20)
      The vast majority of materials used in bone tissue engineering and regenerative medicine are based on calcium phosphates due to their similarity with the mineral phase of natural bone. Among them, calcium ...

    • A mini review focused on the proangiogenic role of silicate ions released from silicon-containing biomaterials 

      Dashnyam, Khandmaa; El-Fiqi, Ahmed; Olmas Buitrago, Jennifer; Pérez Antoñanzas, Roman; C Knowles, Jonathan; Hae-Won, Kim (2017-04-06)
      Angiogenesis is considered an important issue in the development of biomaterials for the successful regeneration of tissues including bone. While growth factors are commonly used with biomaterials to ...

    • Bone morphogenetic protein-6 promotes cerebellar granule neurons survival by activation of the MEK/ERK/CREB pathway 

      Barneda-Zahonero, Bruna; Miñano Molina, Alfredo Jesús; Badiola, Nahuai; Fadó Andrés, Rut; Xifró Collsamata, Xavier; Saura, Carlos A.; Rodríguez Álvarez, José (2009-12-15)
      Bone morphogenetic proteins (BMPs) have been implicated in the generation and postnatal differentiation of cerebellar granule cells (CGCs). Here, we examined the eventual role of BMPs on the survival ...

    • X-linked Inhibitor of Apoptosis Protein negatively regulates neuronal differentiation through interaction with cRAF and Trk 

      Fadó Andrés, Rut; Moubarak, Rana S.; Miñano Molina, Alfredo Jesús; Barneda-Zahonero, Bruna; Valero, Jorge; Saura, Carlos A.; Moran, Julio; Comella, Joan X.; Rodríguez-Álvarez, José (Scientific Reports, 2013-08-09)
      X-linked Inhibitor of apoptosis protein (XIAP) has been classically identified as a cell death regulator. Here, we demonstrate a novel function of XIAP as a regulator of neurite outgrowth in neuronal ...

    • CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy 

      Roa Mansergas, Xavier; Fadó Andrés, Rut; Atari Abouassi, Maher; Mir, Joan Francesc; Muley Vilamú, Helena; Serra, Dolors; Casals i Farré, Núria (Scientific Reports, 2018-05-03)
      Human mesenchymal stem cells (hMSCs) are widely used in regenerative medicine. In some applications, they must survive under low nutrient conditions engendered by avascularity. Strategies to improve ...

    • Mechanisms of CPT1C-Dependent AMPAR trafficking enhancement 

      Gratacòs-Batlle, Esther; Olivella, Mireia; Sánchez-Fernández, Nuria; Yefimenko, Natalia; MIguez-Cabello, Federico; Fadó Andrés, Rut; Casals i Farré, Núria; Gasull, Xavier; Ambrosio, Santiago; Soto, David (Frontiers in Molecular Neuroscience, 2018-08-08)
      In neurons, AMPA receptor (AMPAR) function depends essentially on their constituent components: the ion channel forming subunits and ion channel associated proteins. On the other hand, AMPAR trafficking ...

    • A systematic analysis of orphan cyclins reveals CNTD2 as a new oncogenic driver in lung cancer 

      Gasa Colom, Laura; Sánchez Botet, Abril; Quandt Herrera, Eva; Hernández Ortega, Sara; Jiménez Jiménez, Javier; Carrasco García, Miguel Ángel; Simonetti, Sara; Kron, Stephen J.; P.C. Ribeiro, Mariana; Nadal, E; Villanueva, Alberto; Clotet Erra, Josep (2017-08-31)
      As lung cancer has increased to the most common cause of cancer death worldwide, prognostic biomarkers and efective targeted treatments remain lacking despite advances based on patients’ stratifcation. ...

    • The atypical cyclin CNTD2 promotes colon cancer cell proliferation and migration 

      Sánchez Botet, Abril; Gasa Colom, Laura; Quandt Herrera, Eva; Hernández Ortega, Sara; Jiménez Jiménez, Javier; Mezquita Mas, Pau; Carrasco García, Miguel Ángel; Kron, Stephen J.; Vidal, August; Villanueva, Alberto; P.C. Ribeiro, Mariana; Clotet Erra, Josep (2018-08-07)
      Colorectal cancer (CRC) is one of the most common cancers worldwide, with 8–10% of these tumours presenting a BRAF (V600E) mutation. Cyclins are known oncogenes deregulated in many cancers, but the role ...

    • Phosphoregulation of the oncogenic protein regulator of cytokinesis 1 (PRC1) by the atypical CDK16/CCNY complex 

      Hernández Ortega, Sara; Sánchez Botet, Abril; Quandt Herrera, Eva; Masip, Núria; Gasa Colom, Laura; Verde, Gaetano; Jiménez Jiménez, Javier; Levin, Rebecca; Rugatanira, Florentine U.; Burlingame, Alma L.; Wolfgeher, Donald; P.C. Ribeiro, Mariana; Kron, Stephen J.; M. Shokat, Kevan; Clotet Erra, Josep (2019)
      CDK16 (also known as PCTAIRE1 or PCTK1) is an atypical member of the cyclin-dependent kinase (CDK) family that forms an active complex with cyclin Y (CCNY). Although both proteins have been recently ...

    • Trichoscopy: essentials for the dermatologist 

      Moreno Romero, Juan Antonio; Grimalt Santacana, Ramon (World Journal of Dermatology, 2015-05-02)
      Noninvasive in vivo imaging techniques have become an important diagnostic aid for dermatology. Dermoscopy, also known as dermatoscopy, has been shown to increase the clinician’s diagnostic accuracy ...

    • Use and misuse of PRP clinical trial proposal to help find PRP’s true efficacy 

      Mirallas, Oriol; Farelo, Javier; Grimalt Santacana, Ramon (Journal of Dermatological Research, 2018-04)
      Introduction: Since the early 1970s, Platelet-rich plasma (PRP) has been used in many fields as a potential remedy for having regenerative properties. In dermatology, its use is extended to different ...

    • A linear lesion in a child with atopic dermatitis: not a coincidence 

      Van Gysel, Julie; Grimalt Santacana, Ramon (Clinical Case Reports, 2019-07-25)
      A blaschkolinear lesion in a patient with atopic dermatitis can be a superimposed segmental manifestation of this polygenic disorder. Knowledge of this phenomenon, presence of less severe, disseminated, ...

    • Multichannel functional testing in normal subjects, glaucoma suspects, and glaucoma patients 

      Antón López, Alfonso; Capilla, Pascual; Morilla Grasa, Antonio; Luque, María José; Artigas, José María; Felipe, Adelina (Investigative Ophthalmology & Visual Science, 2012-12)
      Purpose.: To evaluate visual function with a novel multichannel functional test named the ATD Multichannel Functional Test. Methods.: This multicenter study had a prospective and cross-sectional ...

    • Agreement among spectral-domain optical coherence tomography, standard automated perimetry, and stereophotography in the detection of glaucoma progression 

      Banegas Argota, Sebastián Anselmo; Antón López, Alfonso; Morilla Grasa, Antonio; Bogado, Marco; Ayala-Fuentes, Miriam Eleonora; Moreno Montañés, Javier (Investigative Ophthalmology & Visual Science, 2015-02)
      PURPOSE. The purpose of this study was to evaluate the agreement among spectral-domain optical coherence tomography, standard automated perimetry (SAP), and optic disc stereo photography in the detection ...