The atypical cyclin CNTD2 promotes colon cancer cell proliferation and migration
Sánchez Botet, Abril
Gasa Colom, Laura
Quandt Herrera, Eva
Hernández Ortega, Sara
Jiménez Jiménez, Javier
Mezquita Mas, Pau
Carrasco García, Miguel Ángel
Kron, Stephen J.
P.C. Ribeiro, Mariana
Clotet Erra, Josep
Colorectal cancer (CRC) is one of the most common cancers worldwide, with 8–10% of these tumours presenting a BRAF (V600E) mutation. Cyclins are known oncogenes deregulated in many cancers, but the role of the new subfamily of atypical cyclins remains elusive. Here we have performed a systematic analysis of the protein expression levels of eight atypical cyclins in human CRC tumours and several cell lines, and found that CNTD2 is significantly upregulated in CRC tissue compared to the adjacent normal one. CNTD2 overexpression in CRC cell lines increases their proliferation capacity and migration, as well as spheroid formation capacity and anchorage-independent growth. Moreover, CNTD2 increases tumour growth in vivo on xenograft models of CRC with wild-type BRAF. Accordingly, CNTD2 downregulation significantly diminished the proliferation of wild-type BRAF CRC cells, suggesting that CNTD2 may represent a new prognostic factor and a promising drug target in the management of CRC.
616.3 - Patologia de l'aparell digestiu. Odontologia
cáncer de colon
càncer de colon
Sánchez-Botet, A., Gasa, L., Quandt, E., Hernández-Ortega, S., Jiménez, J., Mezquita, P., Carrasco García, M.A., J. Kron, Stephen, Vidal, August, Villanueva, Alberto, Ribeiro, M. P. & Clotet, Josep (2018). «The atypical cyclin CNTD2 promotes colon cancer cell proliferation and migration». Scientific reports, 8(1), 11797.
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