A mini review focused on the proangiogenic role of silicate ions released from silicon-containing biomaterials
Author
Dashnyam, Khandmaa
El-Fiqi, Ahmed
Olmas Buitrago, Jennifer
Pérez Antoñanzas, Roman
C Knowles, Jonathan
Hae-Won, Kim
Publication date
2017-04-06ISSN
2041-7314
Abstract
Angiogenesis is considered an important issue in the development of biomaterials for the successful regeneration of tissues including bone. While growth factors are commonly used with biomaterials to promote angiogenesis, some ions released from biomaterials can also contribute to angiogenic events. Many silica-based biomaterials have been widely used for the repair and regeneration of tissues, mainly hard tissues such as bone and tooth structure. They have shown excellent performance in bone formation by stimulating angiogenesis. The release of silicate and others (Co and Cu ions) has therefore been implicated to play critical roles in the angiogenesis process. In this short review, we highlight the in vitro and in vivo findings of angiogenesis (and the related bone formation) stimulated by the various types of siliconcontaining biomaterials where silicate ions released might play essential roles. We discuss further the possible molecular mechanisms underlying in the ion-induced angiogenic events.
Document Type
Article
Document version
Accepted version
Language
English
Subject (CDU)
616 - Pathology. Clinical medicine
Keywords
Angiogenesis
silicate ions
Neovascularization
bone stimulation
Angiogènesi
Angiogénesis
estimulació òssia
estimulación ósea
iones de silicato
ions de silicat
Pages
13
Publisher
Journal of Tissue Engineering
Citation
Dashnyam, K., El-Fiqi, A., Buitrago, J. O., Perez, R. A., Knowles, J. C., & Kim, H. W. (2017). «A mini review focused on the proangiogenic role of silicate ions released from silicon-containing biomaterials». Journal of tissue engineering, vol. 8, art. 2041731417707339. Disponible en: <https://journals.sagepub.com/doi/10.1177/2041731417707339>. Fecha de acceso: 21 oct. 2019. DOI: 10.1177/2041731417707339
This item appears in the following Collection(s)
- Ciències de la Salut [740]
Rights
https://creativecommons.org/licenses/by/4.0/
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-nd/4.0/