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Long-Term Results of a Phase II Trial of Induction PaclitaxelCarboplatin Followed by Concurrent Radiation Therapy and Weekly Paclitaxel and Consolidation PaclitaxelCarboplatin in Stage III Non-small Cell Lung Cancer
(Journal of Thoracic Oncology, 2011-01)Introduction: Long-term results of a phase II study on the use of induction chemotherapy (CHT) using paclitaxel (P)-carboplatin (C) followed by a concurrent radiation therapy (RT) and weekly P and ... -
Dihydropyrimidine dehydrogenases and cytidine-deaminase gene polymorphisms as outcome predictors in resected gastric cancer patients treated with fluoropyrimidine adjuvant chemotherapy
(Journal of Surgical Oncology, 2008-08-01)Background and Objectives: Single nucleotide polymorphisms of dihydropyrimidine dehydrogenases gene (DPYD) induces dihydropyrimidinedehydrogenase enzyme (DPD) deficiency resulting in increased activity ... -
Low miR-145 and high miR-367 are associated with unfavourable prognosis in resected nonsmall cell lung cancer
(European Respiratory Journal, 2013-04-30)ABSTRACT: The transcription factors SRY-related HMG box (SOX)2 and octamer-binding transcription factor (OCT)4 regulate the expression of the miR-302–367 cluster. miR-145 regulates SOX2 and OCT4 translation ... -
Gene Single Nucleotide PolymorphismAccumulation Improves Survival in Advanced Head and Neck Cancer PatientsTreated With Weekly Paclitaxel
(The Laryngoscope, 2009-08)Objectives/Hypothesis: Single nucleotide polymorphisms (SNPs) of certain genes involved in drug metabolism correlate with survival. Methods: We evaluated the presence of SNPs in six genes (CYP2C8, ... -
Single Nucleotide Polymorphisms in Tobacco Metabolism and DNA Repair Genes and Prognosis in Resected Non-Small-Cell Lung Cancer
(Journal of Surgical Research, 2011-05-01)Background If tobacco-related carcinogens are not inactivated or extruded from the cell, they can damage the DNA. Single nucleotide polymorphisms (SNPs) in genes involved in tobacco metabolism, DNA ... -
Prognostic implications of miR-16 expression levels in resected non-small-cell lung cancer
(Journal of Surgical Oncology, 2010-12-29)Background MicroRNAs are novel regulators of gene expression that are linked to the main oncogene networks, including the p53 pathway. p53 regulates the maturation process of miR-16 and miR-143. We ... -
Health-related quality of life in patients with advanced cancer who express a wish to hasten death: A comparative study
(Palliative Medicine, 2020)Background: Some evidence suggests the wish to hasten death is related to poor health-related quality of life. Deficits in perceived dignity and self-efficacy are risk factors for wish to hasten death ... -
Older Age: A Protective Factor Against Perceived Dignity-Related Distress in Patients With Advanced Cancer?
(Journal of Pain and Symptom Management, 2021)Context Most older adults will face threats to loss of health and social support, which can affect their perceived dignity. Although problems with perceived dignity increase in the context of cancer, ... -
Checklist-based scores overestimate competence in CPR compared with recording strips of manikins in BLS courses
(Resuscitation, 2017-03-07) -
Normative Data of Neuromuscular Function in Upper Limb and Its Correlation with Superficial Fascia and Body Mass Composition
(Applied Sciences, 2026-02-03)Background/Objectives: Neuromuscular functions (NMFs) encompass biomechanical and viscoelastic properties that are essential for coordinated movement and muscular control. While NMFs have been extensively ... -
The Wish to Die in Older Adults and Its Relationship to Burden and Depressive Symptoms in Home Care Workers:A Quasi-Experimental Longitudinal Study
(Journal of Nursing Scholarship, 2025-07-17)Introduction: Older adults may experience a wish to die in the context of deteriorating health, a loss of autonomy, loneliness, or depression. Home care workers may likewise experience burden or symptoms ... -
Enhancing the perceived clinical leadership competence of nursing undergraduates through service-learning unit led by students: A quasi-experimental study
(Nurse Education Today, 2026-01-16)Background: Clinical leadership by nurses is crucial to the provision of safe and high-quality care. Servicelearning activities led by students (often referred to more broadly as community based learning ... -
Impact of a thermal care bundle on perioperative hypothermia, surgical site infection, and readmissions in osteosynthesis patients. A randomised controlled trial.
(European Journal of Anaesthesiology, 2026-02-17)BACKGROUND Maintaining normothermia throughout the perioperative period prevents the occurrence of complications related to hypothermia. OBJECTIVE To determine the effect of a thermal care bundle ... -
Update, validation and cultural adaptation of the Spanish version of the TEAM questionnaire for emergency teams
(International Emergency Nursing, 2026-04-29)Background The Team Emergency Assessment Measure (TEAM) questionnaire is widely used to assess non-technical skills (NTS) in emergency care. An updated and culturally adapted version is needed to ensure ... -
Assessment of empathy by simulated patients: Adaptation and validation of a new instrument
(2026-04-15)Background: Medical doctors’ empathy is vital in their interaction with patients, impacting on patient trust and health outcomes. The Consultation and Relational Empathy (CARE) scale helps assess ... -
Endoscopic vacuum therapy for leaky cavities: is it possible?
(The Spanish Journal of Gastroenterology (Revista Española de Enfermedades Digestivas; REED), 2026)A 71-year-old male patient with a history of bladder neoplasia underwent Bricker-type surgery, during which an iatrogenic rectal injury occurred. During surgery, an unsuccessful suture attempt was made, ... -
Barium enema: Compassionate therapy for refractory colonic diverticular bleeding?
(Gastroenterología y Hepatología, 2023-12) -
Sex-Related Differences in the Phenotype and Course of Inflammatory Bowel Disease: SEXEII Study of ENEIDA
(Clinical Gastroenterology and Hepatology, 2024-11)Background & Aims: The impact of patient sex on the presentation of inflammatory bowel disease (IBD) has been poorly evaluated. Our aims were to assess potential disparities in IBD phenotype and progression ... -
Safety and effectiveness of direct-acting antiviral drugs in the treatment of hepatitis C in patients with inflammatory bowel disease
(Digestive and Liver Disease, 2024-03)Background and aims: Hepatitis C virus (HCV) management in Inflammatory Bowel Disease (IBD) is uncertain. The ECCO guidelines 2021 recommended HCV treatment but warn about the risk of IBD reactivation. ... -
Plastic pigtail vs lumen-apposing metal stents for drainage of walled-off necrosis (PROMETHEUS study): an open-label, multicenter randomized trial
(Surgical Endoscopy, 2024-03-06)Background: Lumen-apposing metal stents (LAMS) have displaced double-pigtail plastic stents (DPS) as the standard treatment for walled-off necrosis (WON),β but evidence for exclusively using LAMS is ...