Recent submissions 

Ciències de la Salut: Recent submissions

Now showing items 941-960 of 979

    • A mini review focused on the proangiogenic role of silicate ions released from silicon-containing biomaterials 

      Dashnyam, Khandmaa; El-Fiqi, Ahmed; Olmas Buitrago, Jennifer; Pérez Antoñanzas, Roman; C Knowles, Jonathan; Hae-Won, Kim (2017-04-06)
      Angiogenesis is considered an important issue in the development of biomaterials for the successful regeneration of tissues including bone. While growth factors are commonly used with biomaterials to ...

    • Bone morphogenetic protein-6 promotes cerebellar granule neurons survival by activation of the MEK/ERK/CREB pathway 

      Barneda-Zahonero, Bruna; Miñano Molina, Alfredo Jesús; Badiola, Nahuai; Fadó Andrés, Rut; Xifró Collsamata, Xavier; Saura, Carlos A.; Rodríguez Álvarez, José (2009-12-15)
      Bone morphogenetic proteins (BMPs) have been implicated in the generation and postnatal differentiation of cerebellar granule cells (CGCs). Here, we examined the eventual role of BMPs on the survival ...

    • X-linked Inhibitor of Apoptosis Protein negatively regulates neuronal differentiation through interaction with cRAF and Trk 

      Fadó Andrés, Rut; Moubarak, Rana S.; Miñano Molina, Alfredo Jesús; Barneda-Zahonero, Bruna; Valero, Jorge; Saura, Carlos A.; Moran, Julio; Comella, Joan X.; Rodríguez-Álvarez, José (Scientific Reports, 2013-08-09)
      X-linked Inhibitor of apoptosis protein (XIAP) has been classically identified as a cell death regulator. Here, we demonstrate a novel function of XIAP as a regulator of neurite outgrowth in neuronal ...

    • CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy 

      Roa Mansergas, Xavier; Fadó Andrés, Rut; Atari Abouassi, Maher; Mir, Joan Francesc; Muley Vilamú, Helena; Serra, Dolors; Casals i Farré, Núria (Scientific Reports, 2018-05-03)
      Human mesenchymal stem cells (hMSCs) are widely used in regenerative medicine. In some applications, they must survive under low nutrient conditions engendered by avascularity. Strategies to improve ...

    • Mechanisms of CPT1C-Dependent AMPAR trafficking enhancement 

      Gratacòs-Batlle, Esther; Olivella, Mireia; Sánchez-Fernández, Nuria; Yefimenko, Natalia; MIguez-Cabello, Federico; Fadó Andrés, Rut; Casals i Farré, Núria; Gasull, Xavier; Ambrosio, Santiago; Soto, David (Frontiers in Molecular Neuroscience, 2018-08-08)
      In neurons, AMPA receptor (AMPAR) function depends essentially on their constituent components: the ion channel forming subunits and ion channel associated proteins. On the other hand, AMPAR trafficking ...

    • A systematic analysis of orphan cyclins reveals CNTD2 as a new oncogenic driver in lung cancer 

      Gasa Colom, Laura; Sánchez Botet, Abril; Quandt Herrera, Eva; Hernández Ortega, Sara; Jiménez Jiménez, Javier; Carrasco García, Miguel Ángel; Simonetti, Sara; Kron, Stephen J.; P.C. Ribeiro, Mariana; Nadal, E; Villanueva, Alberto; Clotet Erra, Josep (2017-08-31)
      As lung cancer has increased to the most common cause of cancer death worldwide, prognostic biomarkers and efective targeted treatments remain lacking despite advances based on patients’ stratifcation. ...

    • The atypical cyclin CNTD2 promotes colon cancer cell proliferation and migration 

      Sánchez Botet, Abril; Gasa Colom, Laura; Quandt Herrera, Eva; Hernández Ortega, Sara; Jiménez Jiménez, Javier; Mezquita Mas, Pau; Carrasco García, Miguel Ángel; Kron, Stephen J.; Vidal, August; Villanueva, Alberto; P.C. Ribeiro, Mariana; Clotet Erra, Josep (2018-08-07)
      Colorectal cancer (CRC) is one of the most common cancers worldwide, with 8–10% of these tumours presenting a BRAF (V600E) mutation. Cyclins are known oncogenes deregulated in many cancers, but the role ...

    • Phosphoregulation of the oncogenic protein regulator of cytokinesis 1 (PRC1) by the atypical CDK16/CCNY complex 

      Hernández Ortega, Sara; Sánchez Botet, Abril; Quandt Herrera, Eva; Masip, Núria; Gasa Colom, Laura; Verde, Gaetano; Jiménez Jiménez, Javier; Levin, Rebecca; Rugatanira, Florentine U.; Burlingame, Alma L.; Wolfgeher, Donald; P.C. Ribeiro, Mariana; Kron, Stephen J.; M. Shokat, Kevan; Clotet Erra, Josep (2019)
      CDK16 (also known as PCTAIRE1 or PCTK1) is an atypical member of the cyclin-dependent kinase (CDK) family that forms an active complex with cyclin Y (CCNY). Although both proteins have been recently ...

    • Trichoscopy: essentials for the dermatologist 

      Moreno Romero, Juan Antonio; Grimalt Santacana, Ramon (World Journal of Dermatology, 2015-05-02)
      Noninvasive in vivo imaging techniques have become an important diagnostic aid for dermatology. Dermoscopy, also known as dermatoscopy, has been shown to increase the clinician’s diagnostic accuracy ...

    • Use and misuse of PRP clinical trial proposal to help find PRP’s true efficacy 

      Mirallas, Oriol; Farelo, Javier; Grimalt Santacana, Ramon (Journal of Dermatological Research, 2018-04)
      Introduction: Since the early 1970s, Platelet-rich plasma (PRP) has been used in many fields as a potential remedy for having regenerative properties. In dermatology, its use is extended to different ...

    • A linear lesion in a child with atopic dermatitis: not a coincidence 

      Van Gysel, Julie; Grimalt Santacana, Ramon (Clinical Case Reports, 2019-07-25)
      A blaschkolinear lesion in a patient with atopic dermatitis can be a superimposed segmental manifestation of this polygenic disorder. Knowledge of this phenomenon, presence of less severe, disseminated, ...

    • Multichannel functional testing in normal subjects, glaucoma suspects, and glaucoma patients 

      Antón López, Alfonso; Capilla, Pascual; Morilla Grasa, Antonio; Luque, María José; Artigas, José María; Felipe, Adelina (Investigative Ophthalmology & Visual Science, 2012-12)
      Purpose.: To evaluate visual function with a novel multichannel functional test named the ATD Multichannel Functional Test. Methods.: This multicenter study had a prospective and cross-sectional ...

    • Agreement among spectral-domain optical coherence tomography, standard automated perimetry, and stereophotography in the detection of glaucoma progression 

      Banegas Argota, Sebastián Anselmo; Antón López, Alfonso; Morilla Grasa, Antonio; Bogado, Marco; Ayala-Fuentes, Miriam Eleonora; Moreno Montañés, Javier (Investigative Ophthalmology & Visual Science, 2015-02)
      PURPOSE. The purpose of this study was to evaluate the agreement among spectral-domain optical coherence tomography, standard automated perimetry (SAP), and optic disc stereo photography in the detection ...

    • In vitro mitomycin C absorption and delivery with different sponge materials used in filtering surgery 

      Urbaneja Mejías, Diana; Morilla Grasa, Antonio; Jiménez, Elisa; Montemayor, Judith; Marcobal, Nuria; Aragay, Carme; Gurdiel, Celia; Armillas, Marta; Ortiz, Pere; Antón López, Alfonso (Clinical Ophthalmology, 2016-02-11)
      Purpose: The purpose of this study is to evaluate and compare mitomycin C (MMC) absorption and delivery in different materials used in filtering surgery. Methods: This is an in vitro study comparing ...

    • Cost and detection rate of glaucoma screening with imaging devices in a primary care center 

      Antón López, Alfonso; Fallon, Mónica; Cots Reguant, Francesc; Sebastian, María A.; Morilla Grasa, Antonio; Mojal, Sergi; Castells, Xavier (Clinical Ophthalmology, 2017-02-16)
      Purpose: To analyze the cost and detection rate of a screening program for detecting glaucoma with imaging devices. Materials and methods: In this cross-sectional study, a glaucoma screening program ...

    • Evaluation of RETICs glaucoma diagnostic calculators in preperimetric glaucoma 

      Moreno Montañés, Javier; García Nieva, Ana; Aristeguieta Osio, Indira; Guarnieri, Adriano; Morilla Grasa, Antonio; García Granero, Marta; Antón López, Alfonso (Translational Vision Science & Technology, 2018-11)
      Purpose: To evaluate two glaucoma diagnostic calculators (GDC) in a group of eyes with preperimetric glaucoma (PPG). Methods: All eyes (n = 265) included in this study had ocular hypertension with ...

    • Automatic glaucoma classification using color fundus images based on convolutional neural networks and transfer learning 

      Gómez-Valverde, Juan J.; Antón López, Alfonso; Fatti, Gianluca; Liefers, Bart; Herranz, Alejandra; Santos, Andrés; Sánchez, Clara I.; Ledesma-Carbayo, María J. (Biomedical Optics Express, 2019-02-01)
      Glaucoma detection in color fundus images is a challenging task that requires expertise and years of practice. In this study we exploited the application of different Convolutional Neural Networks (CNN) ...

    • Effect of femtosecond laser-assisted lens surgery on the optic nerve head and the macula 

      Reñones de Abajo, Josefina; Estévez Jorge, Beatriz; González Martín, Jesús María; Carreras Díaz, Humberto; Loro Ferrer, Juan Francisco; Antón López, Alfonso (2019-06-18)
      Aim: To evaluate the effect of femtosecond laser-assisted lens surgery (FLALS; cataract surgery or refractive lens exchange) on the structure of the optic nerve head and the macula. Methods: This ...

    • Antimicrobial peptides: powerful biorecognition elements to detect bacteria in biosensing technologies 

      Hoyos Nogués, Mireia; Gil Mur, Francisco Javier; Mas Moruno, Carlos (Molecules, 2018-07-10)
      Bacterial infections represent a serious threat in modern medicine. In particular, biofilm treatment in clinical settings is challenging, as biofilms are very resistant to conventional antibiotic therapy ...

    • A dual molecular biointerface combining RGD and KRSR sequences Improves osteoblastic functions by synergizing integrin and cell-membrane proteoglycan binding 

      Hoyos Nogués, Mireia; Falgueras Batlle, Elena; Ginebra Molins, Maria Pau; Manero Planella, José María; Gil Mur, Francisco Javier; Mas Moruno, Carlos (International Journal of Molecular Sciences, 2019-03-21)
      Synergizing integrin and cell-membrane heparan sulfate proteoglycan signaling on biomaterials through peptidic sequences is known to have beneficial effects in the attachment and behavior of osteoblasts; ...