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Application of percutaneous needle electrolysis does not elicit temperature changes: an in vitro cadaveric study
(MDPI, 2022)
Percutaneous needle electrolysis (PNE) consists of the ultrasound-guided application of a galvanic electrical current through a solid filament needle. One proposed therapeutic mechanism for this ...
ADP-ribose–derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling
(American Association for the Advancement of Science, 2016)
Key nuclear processes in eukaryotes, including DNA replication, repair, and gene regulation, require extensive chromatin remodeling catalyzed by energy-consuming enzymes. It remains unclear how the ATP ...
Functional characterization of a novel non-coding mutation “Ghent +49A > G” in the iron-responsive element of L-ferritin causing hereditary hyperferritinaemia-cataract syndrome
(Springer Nature, 2017)
Hereditary hyperferritinaemia-cataract syndrome (HHCS) is a rare disorder usually caused by heterozygous mutations in the iron-responsive element (IRE) in the 5′ untranslated region (5′UTR) of the ...
Maturation of biomimetic hydroxyapatite in physiological fluids: a physicochemical and proteomic study
(Elsevier, 2021-09)
Biomimetic calcium-deficient hydroxyapatite (CDHA) as a bioactive material exhibits exceptional intrinsic osteoinductive and osteogenic properties because of its nanostructure and composition, which ...
Assessing the potential role of copper and cobalt in stimulating angiogenesis for tissue regeneration
(Public Library of Science, 2021)
The use of copper (Cu2+) and cobalt (Co2+) has been described to stimulate blood vessel formation, a key process for the success of tissue regeneration. However, understanding how different concentrations ...
Multiple ion scaffold-based delivery platform for potential application in early stages of bone regeneration
(MDPI, 2021)
Bone has the intrinsic capacity to regenerate itself, as long as the damage is small, through the sequential stimulation of specific phases, such as angiogenesis followed by osteogenesis. However, when ...
Engineered live bacteria suppress Pseudomonas aeruginosa infection in mouse lung and dissolve endotracheal-tube biofilms
(Springer Nature, 2023)
Engineered live bacteria could provide a new modality for treating lung infections, a major cause of mortality worldwide. In the present study, we engineered a genome-reduced human lung bacterium, ...
ATP, Mg2+, nuclear phase separation, and genome accessibility
(Elsevier, 2019)
Misregulation of the processes controlling eukaryotic gene expression can result in disease. Gene expression is influenced by the surrounding chromatin; hence the nuclear environment is also of vital ...
Dissociation of functional and structural plasticity of dendritic spines during NMDAR and mGluR-dependent long-term synaptic depression in wild-type and fragile X model mice
(Springer Nature, 2021)
Many neurodevelopmental disorders are characterized by impaired functional synaptic plasticity and abnormal dendritic spine morphology, but little is known about how these are related. Previous work in ...
Engineering a genome-reduced bacterium to eliminate Staphylococcus aureus biofilms in vivo
(EMBO Press, 2021)
Bacteria present a promising delivery system for treating human diseases. Here, we engineered the genome-reduced human lung pathogen Mycoplasma pneumoniae as a live biotherapeutic to treat biofilm-associated ...