Multiple ion scaffold-based delivery platform for potential application in early stages of bone regeneration
Author
Bosch Rué, Elia
Díez-Tercero, Leire
Rodríguez González, Raquel
A. Pérez, Román
Publication date
2021ISSN
1996-1944
Abstract
Bone has the intrinsic capacity to regenerate itself, as long as the damage is small, through the sequential stimulation of specific phases, such as angiogenesis followed by osteogenesis. However, when the damage is extensive it is unable to regenerate and bone tissue engineering is used as an alternative. In this study, we developed a platform to allow the triple ion delivery with sequential delivery capacity to potentially stimulate antibacterial, angiogenic and osteogenic processes. The scaffold-based platform consisted of alginate/hydroxyapatite (HA) microparticles embedded in alginate fibers. Firstly, microparticles were developed using different ratios of alginate:HA using the spraying method, resulting in a high reproducibility of the technique. Microparticle size between 100–300 µm and ratio 1:40 resulted in a more spherical morphology and were selected for their incorporation into alginate fiber. Different amounts of copper and cobalt were added with the microparticles and alginate fiber, respectively, were used as model ions which could eventually modulate and mimic antimicrobial and angiogenic processes. Moreover, calcium ion was also incorporated in both, in order to provide the system with potential osteogenic properties together with HA. The multiple delivery of copper, cobalt and calcium released were in the therapeutic range as measured by induced coupled plasma (ICP), providing a promising delivery strategy for tissue engineering.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
616.3 - Pathology of the digestive system. Complaints of the alimentary canal
Keywords
Coure
Cobalt
Calci
Alliberament d'ions
Regeneració òssia
Angiogènesi
Osteogènesi
Propietats antimicrobianes
Cobre
Cobalto
Calcio
Liberación de iones
Regeneración ósea
Angiogénesis
Osteogénesis
Propiedades antimicrobianas
Copper
Cobalt
Calcium
Ion release
Bone regeneration
Angiogenesis
Osteogenesis
Antimicrobial properties
Pages
16
Publisher
MDPI
Collection
14; 24
Is part of
Materials
Citation
Bosch-Rué, Èlia; Díez-Tercero, Leire; Rodriguez-Gonzalez, Raquel [et al.]. Multiple ion scaffold-based delivery platform for potential application in early stages of bone regeneration. Materials, 2021, 14(24), 7676. Disponible en: <https://www.mdpi.com/1996-1944/14/24/7676>. Fecha de acceso: 14 ene. 2022. DOI: 10.3390/ma14247676
This item appears in the following Collection(s)
- Ciències Bàsiques [65]
Rights
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/