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Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
(Nature Communications, 2018)With a diverse network of substrates, NUDIX hydrolases have emerged as a key family of nucleotide-metabolizing enzymes. NUDT5 (also called NUDIX5) has been implicated in ADP-ribose and 8-oxo-guanine ... -
Targeting carnitine palmitoyltransferase 1 isoforms in the hypothalamus: a promising strategy to regulate energy balance
(Journal of Neuroendocrinology, 2023)Tackling the growing incidence and prevalence of obesity urgently requires uncovering new molecular pathways with therapeutic potential. The brain, and in particular the hypothalamus, is a major integrator ... -
Targeting DNA repair defects for precision medicine in prostate cancer
(Current Oncology Reports, 2019)Purpose of Review: Genomic studies of localized and metastatic prostate cancer have identified a high prevalence of clinically actionable alterations including mutations in DNA repair genes. In this ... -
Targeting the Src N-terminal regulatory element in cancer
(Oncotarget, 2023)The signaling pathways displayed by cancer cells are often composed by the same components than the physiological ones, yet the overall result is a pathological deregulation. The non-receptor protein ... -
Task-dependent modulation of the visual sensory thalamus assists visual-speech recognition
(NeuroImage, 2018-09)The cerebral cortex modulates early sensory processing via feed-back connections to sensory pathway nuclei. The functions of this top-down modulation for human behavior are poorly understood. Here, we ... -
Telerehabilitation for balance rehabilitation in the subacute stage of stroke: a pilot controlled trial
(NeuroRehabilitation, 2022)BACKGROUND:Telerehabilitation has been proposed as an effective strategy to deliver post-stroke specific exercise. OBJECTIVE:To assess the effectiveness and feasibility of core stability exercises guided ... -
Temperature and current flow effects of different electrode placement in shoulder capacitive-resistive electric transfer applications: a cadaveric study
(BMC Musculoskeletal Disorders, 2021)Background: Impingement syndrome is currently estimated to represent 60% of all shoulder pain disorders. Capacitive-Resistive electric transfer therapy is aimed to provoke temperature and current flow ... -
Temporal validation of a risk prediction model for breast cancer-related lymphoedema in European population: a retrospective study
(Journal of Advanced Nursing, 2023)Aims: To perform temporal validation of a risk prediction model for breast cancer-related lymphoedema in the European population. Design: Temporal validation of a previously developed prediction model ... -
The actin binding protein profilin 2 is a novel regulator of iron homeostasis
(Blood, 2017)Cellular iron homeostasis is controlled by the iron regulatory proteins (IRPs) 1 and 2 that bind cis-regulatory iron-responsive elements (IRE) on target messenger RNAs (mRNA). We identified profilin 2 ... -
The atypical cyclin CNTD2 promotes colon cancer cell proliferation and migration
(2018-08-07)Colorectal cancer (CRC) is one of the most common cancers worldwide, with 8–10% of these tumours presenting a BRAF (V600E) mutation. Cyclins are known oncogenes deregulated in many cancers, but the role ... -
The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation
(Nature Communications, 2012-08-21)Budding yeast cells are assumed to trigger Start and enter the cell cycle only after they attain a critical size set by external conditions. However, arguing against deterministic models of cell size ... -
The effectiveness of extracorporeal shock wave therapy for improving upper limb spasticity and functionality in stroke patients: a systematic review and meta-analysis
(Clinical Rehabilitation, 2020)Objective: To assess the effectiveness of Extracorporeal Shock Wave Therapy for reducing spasticity and improving functionality of the upper limb in stroke survivors. Data sources: A systematic review ... -
The effectiveness of extracorporeal shock wave therapy to reduce lower limb spasticity in stroke patients: a systematic review and meta-analysis
(Topics in Stroke Rehabilitation, 2019)Objective: To assess the effectiveness of Extracorporeal Shock Wave Therapy (ESWT) to reduce lower limb spasticity in adult stroke survivors. Data Sources: A systematic review of Medline/Pubmed, CENTRAL, ... -
The effectiveness of finasteride and dutasteride used for 3 years in women with androgenetic alopecia
(Indian Journal of Dermatology, Venereology and Leprology, 2014-11-01)Background: The effectiveness of finasteride and dutasteride in women with androgenetic alopecia has been the subject of debate. Aim: To evaluate the effectiveness of finasteride and dutasteride on ... -
The effects of alcohol and drugs of abuse on maternal nutritional profile during pregnancy
(Nutrients, 2018)The consumption of alcohol and drugs of abuse among pregnant women has experienced a significant increase in the last decades. Suitable maternal nutritional status is crucial to maintain the optimal ... -
The effects of soft-tissue techniques and exercise in the treatment of patellar tendinopathy - systematic review and meta-analysis
(Healthcare, 2024)Background: Patellar tendinopathy is a degenerative clinical disorder that causes load-related pain in the lower pole of the patella or patellar tendon. It predominantly affects young male athletes ... -
The effects of soft-tissue techniques and exercise in the treatment of patellar tendinopathy—systematic review and meta-analysis
(Healthcare, 2024)Background: Patellar tendinopathy is a degenerative clinical disorder that causes load-related pain in the lower pole of the patella or patellar tendon. It predominantly affects young male athletes ... -
The Efficacy of the proprioceptive neuromuscular facilitation (PNF) approach in stroke rehabilitation to improve basic activities of daily living and quality of life: a systematic review and meta-analysis protocol
(BMJ Open, 2017-12)Introduction Proprioceptive neuromuscular facilitation (PNF) is a widely used rehabilitation concept, although its efficacy has not yet been demonstrated in stroke survivors. The aim of this systematic ... -
The european hematology association roadmap for european hematology research: a consensus document
(Haematologica, 2016)The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical ... -
The HFE gene is associated to an earlier age of onset and to the presence of diabetic nephropathy in diabetes mellitus type 2
(Endocrine, 2004)We initiated the present work to determine whether the presence of the HFE C282Y or H63D mutations could be related to the clinical expression of diabetes mellitus type 2. Two hundred and twenty five ...