The HFE gene is associated to an earlier age of onset and to the presence of diabetic nephropathy in diabetes mellitus type 2
Author
Oliva, Rafael
Novials, Anna
Sánchez, Mayka
Villa, Marga
Ingelmo, Mercedes
Recasens, Mónica
Ascaso, Carlos
Bruguera, Miquel
Gomis, Ramón
Publication date
2004ISSN
1559-0100
Abstract
We initiated the present work to determine whether the presence of the HFE C282Y or H63D mutations could be related to the clinical expression of diabetes mellitus type 2. Two hundred and twenty five type 2 consecutive diabetic patients were included and the HFE genotypes were determined. Younger ages of onset of diabetes as well as a longer duration of the disease were detected in patients carrying at least one C282Y allele (p=0.007). An increased prevalence of retinopathy (p=0.014) and of nephropathy (p=0.04) were also detected in individuals carrying at least one C282Y allele in comparison with patients carrying the other alleles. The increased prevalence of retinopathy in C282Y carriers is related to the increased duration of the disease, but we not have detected that the prevalence of nephropathy is associated with the duration of the disease. However, multivariate logistic regression confirms that the prevalence of nephropathy is higher in the group of patients carrying at least one C282Y allele or the H63D/H63D genotype as compared to the group of patients with the wild-type (N/N) or the N/H63D genotype. To our knowledge our study is the first one to report an earlier age of onset in type 2 diabetic patients carrying HFE mutations.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
61 - Medical sciences
Keywords
Diabetis
HFE
C282Y
H63D
Nefropatia
Retinopatia
Diabetes
HFE
C282Y
H63D
Nefropatía
Retinopatía
Diabetes
HFE
C282Y
H63D
Nephropathy
Retinopathy
Pages
3
Publisher
Springer Nature
Collection
24
Is part of
Endocrine
Citation
Oliva, Rafael; Novials, Anna; Sánchez, Mayka [et al.]. The HFE gene is associated to an earlier age of onset and to the presence of diabetic nephropathy in diabetes mellitus type 2. Endocrine, 2004, 24, p. 111-114. Disponible en: <https://link.springer.com/article/10.1385/ENDO:24:2:111>. Fecha de acceso: 31 ene. 2024. DOI: 10.1385/ENDO:24:2:111
This item appears in the following Collection(s)
- Ciències de la Salut [725]
Rights
© 2004 Springer Nature