Temporal validation of a risk prediction model for breast cancer-related lymphoedema in European population: a retrospective study
Author
Masià, Jaume
Jané, Pau
Publication date
2023ISSN
0309-2402
Abstract
Aims: To perform temporal validation of a risk prediction model for breast cancer-related lymphoedema in the European population. Design: Temporal validation of a previously developed prediction model using a new retrospective cohort of women who had undergone axillary lymph node dissection between June 2018 and June 2020. Methods: We reviewed clinical records to identify women who did and did not develop lymphoedema within 2 years of surgery and to gather data regarding the variables included in the prediction model. The model was calibrated by calculating Spearman's correlation between observed and expected cases. Its accuracy in discriminating between patients who did versus did not develop lymphoedema was assessed by calculating the area under the receiver operating characteristic curve (AUC). Results: The validation cohort comprised 154 women, 41 of whom developed lymphoedema within 2 years of surgery. The value of Spearman's coefficient indicated a strong correlation between observed and expected cases. Sensitivity of the model was higher than in the derivation cohort, as was the value of the AUC. Conclusion: The model shows a good capacity to discriminate women at risk of lymphoedema and may therefore help in developing improved care pathways for individual patients. Implications for the Profession and/or Patient Care: Identifying risk factors for lymphoedema secondary to breast cancer treatment is vital given its impact on women's physical and emotional well-being. Impact: What problem did the study address? Risk of BCRL. What were the main findings? The prediction model has a good capacity to discriminate women at risk of lymphoedema. Where and on whom will the research have an impact? In clinical practice with women at risk of BCRL.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
61 - Medical sciences
Keywords
Càncer de mama
Limfedema relacionat amb el càncer de mama
Infermeria
Model de predicció
Risc
Factors de risc
Corba ROC
Limfedema secundari
Validació temporal
Eina
Cáncer de mama
Linfedema relacionado con cáncer de mama
Enfermería
Modelo de predicción
Riesgo
Factores de riesgo
Curva ROC
Linfedema secundario
Validación temporal
Herramienta
Breast cancer
Breast cancer-related lymphoedema
Nursing
Prediction model
Risk
Risk factors
ROC curve
Secondary lymphoedema
Temporal validation
Tool
Pages
8
Publisher
Wiley
Collection
79; 12
Is part of
Journal of Advanced Nursing
Citation
Martínez-Jaimez, Patricia; Fuster-Linares, Pilar; Masià, Jaume [et al.]. Temporal validation of a risk prediction model for breast cancer-related lymphoedema in European population: a retrospective study. Journal of Advanced Nursing, 2023, 79(12), p. 4707-4715. Disponible en: <https://onlinelibrary.wiley.com/doi/10.1111/jan.15727>. Fecha de acceso: 11 mar. 2024. DOI: 10.1111/jan.15727
This item appears in the following Collection(s)
- Ciències de la Salut [745]
Rights
© 2023 John Wiley & Sons Ltd.