Multiorgan dysfunction in infants of 33-35 weeks gestation with severe hypoxic-ischemic encephalopathy treated with hypothermia anatomy & physiology
Autor/a
Alsina Casanova, Miguel
Martín Ancel, Ana
León Lozano, Marisol
Arca Díaz, Gemma
Pérez Fernández, Elia
García Alix, Alfredo
Data de publicació
2018ISSN
2161-0940
Resum
Background: The benefits of hypothermia on neurodevelopment of newborns ≥ 36 weeks gestation with hypoxicischemic encephalopathy have been shown in large clinical trials. The security of hypothermia in premature infants ≤ 36 weeks has not been rigorously evaluated, although its feasibility has been suggested in recent studies. The present study aims: 1) To describe extraneural involvement in infants 33-35 weeks gestation with severe hypoxicischemic encephalopathy treated with hypothermia 2) To compare organ dysfunction with infants ≥ 36 weeks gestation. Methods: Retrospective observational study of prospective data collected. Consecutive newborns of 33-35 weeks gestation, ≥ 1800g birth weight and severe hypoxic-ischemic encephalopathy were included. Data were compared with a cohort of newborn infants ≥ 36 weeks with severe encephalopathy. Twenty clinical and laboratory variables of 6 organ-systems (cardiovascular, respiratory, renal, haematological, hepatic and pH and electrolytic imbalance) were studied and a multiorgan dysfunction scale was applied daily during the first 3 days of life. Results: Eight preterm newbors with severe HIE were compared with 31 term neonates with severe HIE. All infants presented with moderate-to-severe organ injury. There were no differences in most of organ variables, the number of affected organ-systems or the scores in the Multiorgan dysfunction Scale between both gestational age groups in the first 3 days of life (p>0.05). Conclusion: Organ injury in infants of 33-35 weeks gestation with severe HIE evaluated for hypothermia is not more severe regarding newborns ≥ 36 weeks gestation. Therapeutic hypothermia appears feasible in this gestational age group although clinical trials are needed to answer this question.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
61 - Medicina
Paraules clau
Hipotèrmia
Encefalopatia hipòxico-isquèmica
Disfunció multiorgànica
Òrgan-sistema
Preterm
Hipotermia
Encefalopatía hipóxico-isquémica
Disfunción multiorgánica
Sistema de órganos
Prematuro
Hypothermia
Hypoxic-ischemic encephalopathy
Multiorgan dysfunction
Organ-system
Preterm
Pàgines
7
Publicat per
Longdom Publishing
Col·lecció
8; 4
Publicat a
Anatomy & Physiology: Current Research
Citació
Alsina Casanova, Miguel; Martín Ancel, Ana; León Lozano, Marisol [et al.]. Multiorgan dysfunction in infants of 33-35 weeks gestation with severe hypoxic-ischemic encephalopathy treated with hypothermia anatomy & physiology. Anatomy & Physiology: Current Research, 2018, 8(4), 305. Disponible en: <https://www.longdom.org/open-access/multiorgan-dysfunction-in-infants-of-3335-weeks-gestation-with-severe-hypoxicischemic-encephalopathy-treated-with-hypoth-25348.html>. Fecha de acceso: 7 feb. 2024. DOI: 10.4172/2161-0940.1000305
Aquest element apareix en la col·lecció o col·leccions següent(s)
- Ciències de la Salut [738]
Drets
© 2018 Casanova MA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.