dc.contributor.author | Alsina Casanova, Miguel | |
dc.contributor.author | Martín Ancel, Ana | |
dc.contributor.author | León Lozano, Marisol | |
dc.contributor.author | Arca Díaz, Gemma | |
dc.contributor.author | Pérez Fernández, Elia | |
dc.contributor.author | García Alix, Alfredo | |
dc.date.accessioned | 2024-02-07T10:02:46Z | |
dc.date.available | 2024-02-07T10:02:46Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Alsina Casanova, Miguel; Martín Ancel, Ana; León Lozano, Marisol [et al.]. Multiorgan dysfunction in infants of 33-35 weeks gestation with severe hypoxic-ischemic encephalopathy treated with hypothermia anatomy & physiology. Anatomy & Physiology: Current Research, 2018, 8(4), 305. Disponible en: <https://www.longdom.org/open-access/multiorgan-dysfunction-in-infants-of-3335-weeks-gestation-with-severe-hypoxicischemic-encephalopathy-treated-with-hypoth-25348.html>. Fecha de acceso: 7 feb. 2024. DOI: 10.4172/2161-0940.1000305 | ca |
dc.identifier.issn | 2161-0940 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/4032 | |
dc.description.abstract | Background: The benefits of hypothermia on neurodevelopment of newborns ≥ 36 weeks gestation with hypoxicischemic encephalopathy have been shown in large clinical trials. The security of hypothermia in premature infants ≤ 36 weeks has not been rigorously evaluated, although its feasibility has been suggested in recent studies. The present study aims: 1) To describe extraneural involvement in infants 33-35 weeks gestation with severe hypoxicischemic encephalopathy treated with hypothermia 2) To compare organ dysfunction with infants ≥ 36 weeks gestation. Methods: Retrospective observational study of prospective data collected. Consecutive newborns of 33-35 weeks gestation, ≥ 1800g birth weight and severe hypoxic-ischemic encephalopathy were included. Data were compared with a cohort of newborn infants ≥ 36 weeks with severe encephalopathy. Twenty clinical and laboratory variables of 6 organ-systems (cardiovascular, respiratory, renal, haematological, hepatic and pH and electrolytic imbalance) were studied and a multiorgan dysfunction scale was applied daily during the first 3 days of life. Results: Eight preterm newbors with severe HIE were compared with 31 term neonates with severe HIE. All infants presented with moderate-to-severe organ injury. There were no differences in most of organ variables, the number of affected organ-systems or the scores in the Multiorgan dysfunction Scale between both gestational age groups in the first 3 days of life (p>0.05). Conclusion: Organ injury in infants of 33-35 weeks gestation with severe HIE evaluated for hypothermia is not more severe regarding newborns ≥ 36 weeks gestation. Therapeutic hypothermia appears feasible in this gestational age group although clinical trials are needed to answer this question. | ca |
dc.format.extent | 7 | ca |
dc.language.iso | eng | ca |
dc.publisher | Longdom Publishing | ca |
dc.relation.ispartof | Anatomy & Physiology: Current Research | ca |
dc.relation.ispartofseries | 8;4 | |
dc.rights | © 2018 Casanova MA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | ca |
dc.subject.other | Hipotèrmia | ca |
dc.subject.other | Encefalopatia hipòxico-isquèmica | ca |
dc.subject.other | Disfunció multiorgànica | ca |
dc.subject.other | Òrgan-sistema | ca |
dc.subject.other | Preterm | ca |
dc.subject.other | Hipotermia | ca |
dc.subject.other | Encefalopatía hipóxico-isquémica | ca |
dc.subject.other | Disfunción multiorgánica | ca |
dc.subject.other | Sistema de órganos | ca |
dc.subject.other | Prematuro | ca |
dc.subject.other | Hypothermia | ca |
dc.subject.other | Hypoxic-ischemic encephalopathy | ca |
dc.subject.other | Multiorgan dysfunction | ca |
dc.subject.other | Organ-system | ca |
dc.subject.other | Preterm | ca |
dc.title | Multiorgan dysfunction in infants of 33-35 weeks gestation with severe hypoxic-ischemic encephalopathy treated with hypothermia anatomy & physiology | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 61 | ca |
dc.identifier.doi | https://dx.doi.org/10.4172/2161-0940.1000305 | ca |