Statins in cancer prevention and therapy
Publication date
2023ISSN
2072-6694
Abstract
Statins, a class of HMG-CoA reductase inhibitors best known for their cholesterol-reducing and cardiovascular protective activity, have also demonstrated promise in cancer prevention and treatment. This review focuses on their potential applications in head and neck cancer (HNC), a common malignancy for which established treatment often fails despite incurring debilitating adverse effects. Preclinical and clinical studies have suggested that statins may enhance HNC sensitivity to radiation and other conventional therapies while protecting normal tissue, but the underlying mechanisms remain poorly defined, likely involving both cholesterol-dependent and -independent effects on diverse cancer-related pathways. This review brings together recent discoveries concerning the anticancer activity of statins relevant to HNC, highlighting their anti-inflammatory activity and impacts on DNA-damage response. We also explore molecular targets and mechanisms and discuss the potential to integrate statins into conventional HNC treatment regimens to improve patient outcomes.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
61 - Medical sciences
Keywords
Càncer de cap i coll
Estatina
Colesterol
Prenilació
Teràpia del càncer
Prevenció
Cáncer de cabeza y cuello
Estatina
Colesterol
Prenilación
Terapia del cáncer
Prevención
Head and neck cancer
Statin
Cholesterol
Prenylation
Cancer therapy
Prevention
Pages
19
Publisher
MDPI
Collection
15
Is part of
Cancers
Citation
Ricco Pacheco, Andrea; Natalia Kron, Stephen J.. Statins in cancer prevention and therapy. Cancers, 2023, 15(15), 3948. Disponible en: <https://www.mdpi.com/2072-6694/15/15/3948>. Fecha de acceso: 6 nov. 2023. DOI: 10.3390/cancers15153948
This item appears in the following Collection(s)
- Ciències de la Salut [738]
Rights
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/