Statins in cancer prevention and therapy
Data de publicació
2023ISSN
2072-6694
Resum
Statins, a class of HMG-CoA reductase inhibitors best known for their cholesterol-reducing and cardiovascular protective activity, have also demonstrated promise in cancer prevention and treatment. This review focuses on their potential applications in head and neck cancer (HNC), a common malignancy for which established treatment often fails despite incurring debilitating adverse effects. Preclinical and clinical studies have suggested that statins may enhance HNC sensitivity to radiation and other conventional therapies while protecting normal tissue, but the underlying mechanisms remain poorly defined, likely involving both cholesterol-dependent and -independent effects on diverse cancer-related pathways. This review brings together recent discoveries concerning the anticancer activity of statins relevant to HNC, highlighting their anti-inflammatory activity and impacts on DNA-damage response. We also explore molecular targets and mechanisms and discuss the potential to integrate statins into conventional HNC treatment regimens to improve patient outcomes.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
61 - Medicina
Paraules clau
Càncer de cap i coll
Estatina
Colesterol
Prenilació
Teràpia del càncer
Prevenció
Cáncer de cabeza y cuello
Estatina
Colesterol
Prenilación
Terapia del cáncer
Prevención
Head and neck cancer
Statin
Cholesterol
Prenylation
Cancer therapy
Prevention
Pàgines
19
Publicat per
MDPI
Col·lecció
15
Publicat a
Cancers
Citació
Ricco Pacheco, Andrea; Natalia Kron, Stephen J.. Statins in cancer prevention and therapy. Cancers, 2023, 15(15), 3948. Disponible en: <https://www.mdpi.com/2072-6694/15/15/3948>. Fecha de acceso: 6 nov. 2023. DOI: 10.3390/cancers15153948
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Drets
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Excepte que s'indiqui una altra cosa, la llicència de l'ítem es descriu com https://creativecommons.org/licenses/by/4.0/