Nanomedicine targeting brain lipid metabolism as a feasible approach for controlling the energy balance
Autor/a
Garcia-Chica, Jesús
Zagmutt, Sebastián
Fosch, Anna
Reguera, Ana Cristina
Alzina, Sara
Sánchez-García, Laura
Fukushima, Shigeto
Toh, Kazuko
Casals, Núria
Serra, Dolors
Herrero, Laura
Kataoka, Kazunori
Ariza, Xavier
Rodriguez-Rodriguez, Rosalia
Fecha de publicación
2023ISSN
2047-4849
Resumen
Targeting brain lipid metabolism is a promising strategy to regulate the energy balance and fight metabolic diseases such as obesity. The development of stable platforms for selective delivery of drugs, particularly to the hypothalamus, is a challenge but a possible solution for these metabolic diseases. Attenuating fatty acid oxidation in the hypothalamus via CPT1A inhibition leads to satiety, but this target is difficult to reach in vivo with the current drugs. We propose using an advanced crosslinked polymeric micelle-type nanomedicine that can stably load the CPT1A inhibitor C75-CoA for in vivo control of the energy balance. Central administration of the nanomedicine induced a rapid attenuation of food intake and body weight in mice via regulation of appetite-related neuropeptides and neuronal activation of specific hypothalamic regions driving changes in the liver and adipose tissue. This nanomedicine targeting brain lipid metabolism was successful in the modulation of food intake and peripheral metabolism in mice.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
Inglés
Materias (CDU)
615 - Farmacología. Terapéutica. Toxicología. Radiología
Palabras clave
Metabolisme
Fàrmacs
Metabolismo
Fármacos
Metabolism
Drugs
Páginas
12
Publicado por
Royal Society of Chemistry
Publicado en
Biomaterials Science
Citación
Garcia-Chica, Jesús; Paraiso, West Kristian; Zagmutt, Sebastián [et al.]. Nanomedicine targeting brain lipid metabolism as a feasible approach for controlling the energy balance. Biomaterials Science, 2023, [p. 1-12]. Disponible en: <https://pubs.rsc.org/en/content/articlelanding/2023/BM/D2BM01751B>. Fecha de acceso: 22 mar. 2023. DOI: 10.1039/D2BM01751B
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This article is Open Access.
Excepto si se señala otra cosa, la licencia del ítem se describe como https://creativecommons.org/licenses/by-nc/3.0/