Browsing by Subject "Metabolismo"
Now showing items 1-11 of 11
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Current challenges for targeting brown fat thermogenesis to combat obesity
(Frontiers in Endocrinology, 2020-10-27)Just over a decade has passed since metabolically active brown adipose tissue (BAT) was unequivocally identified in healthy adult humans. Since then, researchers have provided evidence of expression of ... -
Development of a serum-free medium to aid large-scale production of mycoplasma-based therapies
(Microbiology Spectrum, 2023)To assist in the advancement of the large-scale production of safe Mycoplasma vaccines and other Mycoplasma-based therapies, we developed a culture medium free of animal serum and other animal components ... -
Hypothalamic AMPK-ER Stress-JNK1 axis mediates the central actions of thyroid hormones on energy balance
(Cell Metabolism, 2017-07)Thyroid hormones (THs) act in the brain to modulate energy balance. We show that central triiodothyronine (T3) regulates de novo lipogenesis in liver and lipid oxidation in brown adipose tissue (BAT) ... -
Implication between genetic variants from APOA5 and ZPR1 and NAFLD severity in patients with hypertriglyceridemia
(Nutrients, 2021)Background: Lipid metabolism disorders, especially hypertriglyceridemia (HTG), are risk factors for non-alcoholic fatty liver disease (NAFLD). However, the association between genetic factors related ... -
Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype
(Nature Metabolism, 2023)Fibrogenesis is part of a normal protective response to tissue injury that can become irreversible and progressive, leading to fatal diseases. Senescent cells are a main driver of fibrotic diseases ... -
Molecular evolution of multiple-level control of heme biosynthesis pathway in animal kingdom
(PLoS One, 2014)Adaptation of enzymes in a metabolic pathway can occur not only through changes in amino acid sequences but also through variations in transcriptional activation, mRNA splicing and mRNA translation. The ... -
Nanomedicine targeting brain lipid metabolism as a feasible approach for controlling the energy balance
(Biomaterials Science, 2023)Targeting brain lipid metabolism is a promising strategy to regulate the energy balance and fight metabolic diseases such as obesity. The development of stable platforms for selective delivery of drugs, ... -
Pomace olive oil concentrated in triterpenic acids restores vascular function, glucose tolerance and obesity progression in mice
(Nutrients, 2020-01)Pomace olive oil, an olive oil sub-product, is a promising source of bioactive triterpenoids such as oleanolic acid and maslinic acid. Considering the vascular actions of pomace olive oil and the potential ... -
SIREs 3.0, an improved RNA prediction tool for iron-responsive elements
(Nucleic Acids Research, 2025)Iron-responsive elements (IREs) are cis-acting regulatory RNA motifs that bind to iron regulatory proteins (IRP1 and IRP2), playing an essential role in the post-transcriptional regulation of genes ... -
Structural (betaalpha) 8 TIM barrel model of 3-hydroxy-3-methylglutaryl-coenzyme A lyase
(Journal of Biological Chemistry, 2003)This study describes three novel homozygous missense mutations (S75R, S201Y, and D204N) in the 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) lyase gene, which caused 3-hydroxy-3-methylglutaric aciduria in ... -
The return of malonyl-CoA to the brain: cognition and other stories
(Progress in Lipid Research, 2021-01)Nutrients, hormones and the energy sensor AMP-activated protein kinase (AMPK) tightly regulate the intracel-lular levels of the metabolic intermediary malonyl-CoA, which is a precursor of fatty ...