Nanomedicine targeting brain lipid metabolism as a feasible approach for controlling the energy balance
Autor/a
Garcia-Chica, Jesús
Zagmutt, Sebastián
Fosch, Anna
Reguera, Ana Cristina
Alzina, Sara
Sánchez-García, Laura
Fukushima, Shigeto
Toh, Kazuko
Casals, Núria
Serra, Dolors
Herrero, Laura
Kataoka, Kazunori
Ariza, Xavier
Rodriguez-Rodriguez, Rosalia
Data de publicació
2023ISSN
2047-4849
Resum
Targeting brain lipid metabolism is a promising strategy to regulate the energy balance and fight metabolic diseases such as obesity. The development of stable platforms for selective delivery of drugs, particularly to the hypothalamus, is a challenge but a possible solution for these metabolic diseases. Attenuating fatty acid oxidation in the hypothalamus via CPT1A inhibition leads to satiety, but this target is difficult to reach in vivo with the current drugs. We propose using an advanced crosslinked polymeric micelle-type nanomedicine that can stably load the CPT1A inhibitor C75-CoA for in vivo control of the energy balance. Central administration of the nanomedicine induced a rapid attenuation of food intake and body weight in mice via regulation of appetite-related neuropeptides and neuronal activation of specific hypothalamic regions driving changes in the liver and adipose tissue. This nanomedicine targeting brain lipid metabolism was successful in the modulation of food intake and peripheral metabolism in mice.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
615 - Farmacologia. Terapèutica. Toxicologia. Radiologia
Paraules clau
Metabolisme
Fàrmacs
Metabolismo
Fármacos
Metabolism
Drugs
Pàgines
12
Publicat per
Royal Society of Chemistry
Publicat a
Biomaterials Science
Citació
Garcia-Chica, Jesús; Paraiso, West Kristian; Zagmutt, Sebastián [et al.]. Nanomedicine targeting brain lipid metabolism as a feasible approach for controlling the energy balance. Biomaterials Science, 2023, [p. 1-12]. Disponible en: <https://pubs.rsc.org/en/content/articlelanding/2023/BM/D2BM01751B>. Fecha de acceso: 22 mar. 2023. DOI: 10.1039/D2BM01751B
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Drets
This article is Open Access.
Excepte que s'indiqui una altra cosa, la llicència de l'ítem es descriu com https://creativecommons.org/licenses/by-nc/3.0/