Mad3 modulates the G1 Cdk and acts as a timer in the Start network
Pérez, Alexis P.
Artés, Marta H.
Cells maintain their size within limits over successive generations to maximize fitness and survival. Sizer, timer, and adder behaviors have been proposed as possible alternatives to coordinate growth and cell cycle progression. Regarding budding yeast cells, a sizer mechanism is thought to rule cell cycle entry at Start. However, while many proteins controlling the size of these cells have been identified, the mechanistic framework in which they participate to achieve cell size homeostasis is not understood. We show here that intertwined APC and SCF degradation machineries with specific adaptor proteins drive cyclic accumulation of the G1 Cdk in the nucleus, reaching maximal levels at Start. The mechanism incorporates Mad3, a centromeric-signaling protein that subordinates G1 progression to the previous mitosis as a memory factor. This alternating-degradation device displays the properties of a timer and, together with the sizer device, would constitute a key determinant of cell cycle entry.
576 - Cellular and subcellular biology. Cytology
American Association for the Advancement of Science
Is part of
Pérez, Alexis P; Artés, Marta H.; Moreno, David F. [et al.]. Mad3 modulates the G1 Cdk and acts as a timer in the Start network- Science Advances, 2022, 8(18), p. 1-11. Disponible en: <https://www.science.org/doi/10.1126/sciadv.abm4086>. Fecha de acceso: 3 jun. 2022. DOI: 10.1126/sciadv.abm4086
Link to the related item
This item appears in the following Collection(s)
- Ciències de la Salut 
© 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc/4.0/