Mad3 modulates the G1 Cdk and acts as a timer in the Start network
Visualitza/Obre
Data de publicació
2022ISSN
2375-2548
Resum
Cells maintain their size within limits over successive generations to maximize fitness and survival. Sizer, timer, and adder behaviors have been proposed as possible alternatives to coordinate growth and cell cycle progression. Regarding budding yeast cells, a sizer mechanism is thought to rule cell cycle entry at Start. However, while many proteins controlling the size of these cells have been identified, the mechanistic framework in which they participate to achieve cell size homeostasis is not understood. We show here that intertwined APC and SCF degradation machineries with specific adaptor proteins drive cyclic accumulation of the G1 Cdk in the nucleus, reaching maximal levels at Start. The mechanism incorporates Mad3, a centromeric-signaling protein that subordinates G1 progression to the previous mitosis as a memory factor. This alternating-degradation device displays the properties of a timer and, together with the sizer device, would constitute a key determinant of cell cycle entry.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
576 - Biologia cel·lular i subcel·lular. Citologia
Paraules clau
Células
Ciclo celular
Biologia cel·lular
Células
Ciclo celular
Biología celular
Cells
Cell cycle
Cell biology
Pàgines
11
Publicat per
American Association for the Advancement of Science
Col·lecció
8; 18
Publicat a
Science Advances
Citació
Pérez, Alexis P; Artés, Marta H.; Moreno, David F. [et al.]. Mad3 modulates the G1 Cdk and acts as a timer in the Start network- Science Advances, 2022, 8(18), p. 1-11. Disponible en: <https://www.science.org/doi/10.1126/sciadv.abm4086>. Fecha de acceso: 3 jun. 2022. DOI: 10.1126/sciadv.abm4086
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Drets
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