Mad3 modulates the G1 Cdk and acts as a timer in the Start network
Fecha de publicación
2022ISSN
2375-2548
Resumen
Cells maintain their size within limits over successive generations to maximize fitness and survival. Sizer, timer, and adder behaviors have been proposed as possible alternatives to coordinate growth and cell cycle progression. Regarding budding yeast cells, a sizer mechanism is thought to rule cell cycle entry at Start. However, while many proteins controlling the size of these cells have been identified, the mechanistic framework in which they participate to achieve cell size homeostasis is not understood. We show here that intertwined APC and SCF degradation machineries with specific adaptor proteins drive cyclic accumulation of the G1 Cdk in the nucleus, reaching maximal levels at Start. The mechanism incorporates Mad3, a centromeric-signaling protein that subordinates G1 progression to the previous mitosis as a memory factor. This alternating-degradation device displays the properties of a timer and, together with the sizer device, would constitute a key determinant of cell cycle entry.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
English
Materias (CDU)
576 - Biología celular y subcelular. Citología
Palabras clave
Células
Ciclo celular
Biologia cel·lular
Células
Ciclo celular
Biología celular
Cells
Cell cycle
Cell biology
Páginas
11
Publicado por
American Association for the Advancement of Science
Colección
8; 18
Publicado en
Science Advances
Citación
Pérez, Alexis P; Artés, Marta H.; Moreno, David F. [et al.]. Mad3 modulates the G1 Cdk and acts as a timer in the Start network- Science Advances, 2022, 8(18), p. 1-11. Disponible en: <https://www.science.org/doi/10.1126/sciadv.abm4086>. Fecha de acceso: 3 jun. 2022. DOI: 10.1126/sciadv.abm4086
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