Bone mineral density, pulmonary function, chronological age, and age at diagnosis in children and adolescents with cystic fibrosis
Donadio, Márcio V.F.
De Souza, Guilherme C.
Heinzmann-Filho, João P.
Paim, Taísa F.
Hommerding, Patrícia X.
Marosticaf, Paulo J.C.
Densidade mineral óssea, função pulmonar, idade cronológica e idade de diagnóstico em crianças e adolescentes com fibrose cística
Objective: To assess bone mineral density in patients with cystic fibrosis (CF), and to correlate it with possible intervening variables. Methods: Children and adolescents diagnosed with CF, aged 6 to 18 years, followed at the outpatient clinic were included in the study. First, demographic data were collected and, subsequently, patients underwent a spirometric test. All patients answered the Cystic Fibrosis Quality of Life Questionnaire (CFQ) and underwent the six-minute walk test (6MWT) and bone densitometry (DXA). Results: A total of 25 CF patients were included, of which 56% were males. The mean age was 12.3±3.4 years; mean height was 149.2±14.4 cm; and mean weight was 44.4±13.9 kg. Most results on pulmonary function and bone mineral density (BMD) were within normal limits. The mean forced expiratory volume in one second (FEV) was 92.5±23.6 (% of predicted), mean forced vital capacity (FVC) was 104.4±21.3 (% of predicted), and1 mean BMD z-score was 0.1±1.0. BMD was moderately correlated with FEV (r = 0.43, p = 0.03) and FVC (r = 0.57, p = 0.003). Regarding chronological age and age at diagnosis, a moderate and inverse correlation was also found (r = −0.55, p = 0.004; r = −0.57, p = 0.003, respectively). However, no significant correlations were found with the data from CFQ, 6MWT, and body mass index. Conclusion: Most patients had BMD within normal limits and presented a positive correlation with pulmonary function, as well as a negative correlation with chronological age and age at diagnosis.
61 - Medicina
616.7 - Patologia dels òrgans de la locomoció. Sistema locomotor i esquelètic
Densitat mineral òssia
Densidad mineral ósea
Bone mineral density
Is part of
Jornal de Pediatria
Donadio, Márcio V.F.; De Souza, Guilherme C.; Tiecher, Gabriele [et al.]. Bone mineral density, pulmonary function, chronological age, and age at diagnosis in children and adolescents with cystic fibrosis. Jornal de Pediatria, 2013, 89(2), p. 151-157. Disponible en: <https://www.sciencedirect.com/science/article/pii/S0021755713000259?via%3Dihub>. Fecha de acceso: 1 abr. 2022. DOI: 10.1016/j.jped.2013.03.008
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