Bone mineral density, pulmonary function, chronological age, and age at diagnosis in children and adolescents with cystic fibrosis
Author
Donadio, Márcio V.F.
De Souza, Guilherme C.
Tiecher, Gabriele
Heinzmann-Filho, João P.
Paim, Taísa F.
Hommerding, Patrícia X.
Marosticaf, Paulo J.C.
Publication date
2013Alternative title
Densidade mineral óssea, função pulmonar, idade cronológica e idade de diagnóstico em crianças e adolescentes com fibrose cística
ISSN
0021-7557
Abstract
Objective: To assess bone mineral density in patients with cystic fibrosis (CF), and to correlate it with possible intervening variables. Methods: Children and adolescents diagnosed with CF, aged 6 to 18 years, followed at the outpatient clinic were included in the study. First, demographic data were collected and, subsequently, patients underwent a spirometric test. All patients answered the Cystic Fibrosis Quality of Life Questionnaire (CFQ) and underwent the six-minute walk test (6MWT) and bone densitometry (DXA). Results: A total of 25 CF patients were included, of which 56% were males. The mean age was 12.3±3.4 years; mean height was 149.2±14.4 cm; and mean weight was 44.4±13.9 kg. Most results on pulmonary function and bone mineral density (BMD) were within normal limits. The mean forced expiratory volume in one second (FEV) was 92.5±23.6 (% of predicted), mean forced vital capacity (FVC) was 104.4±21.3 (% of predicted), and1 mean BMD z-score was 0.1±1.0. BMD was moderately correlated with FEV (r = 0.43, p = 0.03) and FVC (r = 0.57, p = 0.003). Regarding chronological age and age at diagnosis, a moderate and inverse correlation was also found (r = −0.55, p = 0.004; r = −0.57, p = 0.003, respectively). However, no significant correlations were found with the data from CFQ, 6MWT, and body mass index. Conclusion: Most patients had BMD within normal limits and presented a positive correlation with pulmonary function, as well as a negative correlation with chronological age and age at diagnosis.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
61 - Medical sciences
616.7 - Pathology of the organs of locomotion. Skeletal and locomotor systems
Keywords
Densitat mineral òssia
Fibrosi quística
Funció pulmonar
Densidad mineral ósea
Fibrosis quística
Función pulmonar
Bone mineral density
Cystic fibrosis
Pulmonary function
Pages
7
Publisher
Elsevier
Collection
89; 2
Is part of
Jornal de Pediatria
Citation
Donadio, Márcio V.F.; De Souza, Guilherme C.; Tiecher, Gabriele [et al.]. Bone mineral density, pulmonary function, chronological age, and age at diagnosis in children and adolescents with cystic fibrosis. Jornal de Pediatria, 2013, 89(2), p. 151-157. Disponible en: <https://www.sciencedirect.com/science/article/pii/S0021755713000259?via%3Dihub>. Fecha de acceso: 1 abr. 2022. DOI: 10.1016/j.jped.2013.03.008
This item appears in the following Collection(s)
- Ciències de la Salut [736]
Rights
Under a Creative Commons license.
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc-nd/4.0/