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dc.contributor.authorWright, Roni H.G.
dc.contributor.authorBeato, Miguel
dc.date.accessioned2021-12-14T15:10:40Z
dc.date.available2021-12-14T15:10:40Z
dc.date.issued2021
dc.identifier.citationWright, Roni H. G.; Beato, Miguel. Role of the NUDT enzymes in breast cancer. International Journal of Molecular Sciences, 2021, 22(5), 2267. Disponible en: <https://www.mdpi.com/1422-0067/22/5/2267>. Fecha de acceso: 14 dic. 2021. DOI: 10.3390/ijms22052267ca
dc.identifier.issn1422-0067ca
dc.identifier.urihttp://hdl.handle.net/20.500.12328/3018
dc.description.abstractDespite global research efforts, breast cancer remains the leading cause of cancer death in women worldwide. The majority of these deaths are due to metastasis occurring years after the initial treatment of the primary tumor and occurs at a higher frequency in hormone receptor-positive (Estrogen and Progesterone; HR+) breast cancers. We have previously described the role of NUDT5 (Nudix-linked to moiety X-5) in HR+ breast cancer progression, specifically with regards to the growth of breast cancer stem cells (BCSCs). BCSCs are known to be the initiators of epithelial-to-mesenchyme transition (EMT), metastatic colonization, and growth. Therefore, a greater understanding of the proteins and signaling pathways involved in the metastatic process may open the door for therapeutic opportunities. In this review, we discuss the role of NUDT5 and other members of the NUDT family of enzymes in breast and other cancer types. We highlight the use of global omics data based on our recent phosphoproteomic analysis of progestin signaling pathways in breast cancer cells and how this experimental approach provides insight into novel crosstalk mechanisms for stratification and drug discovery projects aiming to treat patients with aggressive cancer.en
dc.format.extent14ca
dc.language.isoengca
dc.publisherMDPIca
dc.relation.ispartofInternational Journal of Molecular Sciencesca
dc.relation.ispartofseries22;5
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.otherCàncer de pulmóca
dc.subject.otherDescobriment de fàrmacsca
dc.subject.otherInhibidorsca
dc.subject.otherCèl·lules mare cancerígenesca
dc.subject.otherReceptors hormonalsca
dc.subject.otherMetàstasica
dc.subject.otherLung canceren
dc.subject.otherDrug discoveryen
dc.subject.otherInhibitorsen
dc.subject.otherCarcinogenic stem cellsen
dc.subject.otherHormone receptorsen
dc.subject.otherMetastasisen
dc.subject.otherCáncer de pulmónes
dc.subject.otherDescubrimiento de fármacoses
dc.subject.otherInhibidoreses
dc.subject.otherCélulas madre cancerígenases
dc.subject.otherReceptores hormonaleses
dc.subject.otherMetástasises
dc.titleRole of the NUDT enzymes in breast canceren
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc61ca
dc.subject.udc616ca
dc.identifier.doihttps://dx.doi.org/10.3390/ijms22052267ca


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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/
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