Role of the NUDT enzymes in breast cancer
Wright, Roni H.G.
Despite global research efforts, breast cancer remains the leading cause of cancer death in women worldwide. The majority of these deaths are due to metastasis occurring years after the initial treatment of the primary tumor and occurs at a higher frequency in hormone receptor-positive (Estrogen and Progesterone; HR+) breast cancers. We have previously described the role of NUDT5 (Nudix-linked to moiety X-5) in HR+ breast cancer progression, specifically with regards to the growth of breast cancer stem cells (BCSCs). BCSCs are known to be the initiators of epithelial-to-mesenchyme transition (EMT), metastatic colonization, and growth. Therefore, a greater understanding of the proteins and signaling pathways involved in the metastatic process may open the door for therapeutic opportunities. In this review, we discuss the role of NUDT5 and other members of the NUDT family of enzymes in breast and other cancer types. We highlight the use of global omics data based on our recent phosphoproteomic analysis of progestin signaling pathways in breast cancer cells and how this experimental approach provides insight into novel crosstalk mechanisms for stratification and drug discovery projects aiming to treat patients with aggressive cancer.
61 - Medicina
616 - Patologia. Medicina clínica. Oncologia
Càncer de pulmó
Descobriment de fàrmacs
Cèl·lules mare cancerígenes
Carcinogenic stem cells
Cáncer de pulmón
Descubrimiento de fármacos
Células madre cancerígenas
Is part of
International Journal of Molecular Sciences
Wright, Roni H. G.; Beato, Miguel. Role of the NUDT enzymes in breast cancer. International Journal of Molecular Sciences, 2021, 22(5), 2267. Disponible en: <https://www.mdpi.com/1422-0067/22/5/2267>. Fecha de acceso: 14 dic. 2021. DOI: 10.3390/ijms22052267
This item appears in the following Collection(s)
- Ciències de la Salut 
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/