Role of the NUDT enzymes in breast cancer
Autor/a
Wright, Roni H.G.
Beato, Miguel
Fecha de publicación
2021ISSN
1422-0067
Resumen
Despite global research efforts, breast cancer remains the leading cause of cancer death in women worldwide. The majority of these deaths are due to metastasis occurring years after the initial treatment of the primary tumor and occurs at a higher frequency in hormone receptor-positive (Estrogen and Progesterone; HR+) breast cancers. We have previously described the role of NUDT5 (Nudix-linked to moiety X-5) in HR+ breast cancer progression, specifically with regards to the growth of breast cancer stem cells (BCSCs). BCSCs are known to be the initiators of epithelial-to-mesenchyme transition (EMT), metastatic colonization, and growth. Therefore, a greater understanding of the proteins and signaling pathways involved in the metastatic process may open the door for therapeutic opportunities. In this review, we discuss the role of NUDT5 and other members of the NUDT family of enzymes in breast and other cancer types. We highlight the use of global omics data based on our recent phosphoproteomic analysis of progestin signaling pathways in breast cancer cells and how this experimental approach provides insight into novel crosstalk mechanisms for stratification and drug discovery projects aiming to treat patients with aggressive cancer.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
Inglés
Materias (CDU)
61 - Medicina
616 - Patología. Medicina clínica. Oncología
Palabras clave
Càncer de pulmó
Descobriment de fàrmacs
Inhibidors
Cèl·lules mare cancerígenes
Receptors hormonals
Metàstasi
Lung cancer
Drug discovery
Inhibitors
Carcinogenic stem cells
Hormone receptors
Metastasis
Cáncer de pulmón
Descubrimiento de fármacos
Inhibidores
Células madre cancerígenas
Receptores hormonales
Metástasis
Páginas
14
Publicado por
MDPI
Colección
22;5
Publicado en
International Journal of Molecular Sciences
Citación
Wright, Roni H. G.; Beato, Miguel. Role of the NUDT enzymes in breast cancer. International Journal of Molecular Sciences, 2021, 22(5), 2267. Disponible en: <https://www.mdpi.com/1422-0067/22/5/2267>. Fecha de acceso: 14 dic. 2021. DOI: 10.3390/ijms22052267
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Derechos
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