Mostrar el registro sencillo del ítem
High effectiveness of a 14-day concomitant therapy for helicobacter pylori treatment in primary care. An observational multicenter study
dc.contributor.author | Olmedo, Llum | |
dc.contributor.author | Azagra, Rafael | |
dc.contributor.author | Aguyé, Amada | |
dc.contributor.author | Pascual, Marta | |
dc.contributor.author | Calvet, Xavier | |
dc.contributor.author | Gené Tous, Emilio Miguel | |
dc.date.accessioned | 2021-09-21T11:40:19Z | |
dc.date.available | 2021-09-21T11:40:19Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Olmedo, Llum; Azagra, Rafael; Aguyé, Amada [et al.]. High effectiveness of a 14-day concomitant therapy for helicobacter pylori treatment in primary care. An observational multicenter study. Journal of Clinical Medicine, 2020, 9(8), 2410. Disponible en: <https://www.mdpi.com/2077-0383/9/8/2410>. Fecha de acceso: 21 sep. 2021. DOI: 10.3390/jcm9082410 | ca |
dc.identifier.issn | 2077-0383 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/2808 | |
dc.description.abstract | Background: The current cure rates with triple therapy combining a proton-pump inhibitor, amoxicillin and clarithromycin are unacceptably low. Aims: To evaluate the efficacy of a 14-day concomitant therapy as an empirical first-line treatment for curing Helicobacter pylori (Hp) infection in primary care. Methods: Patients from six primary care centers in Catalonia -Spain- were included consecutively. Hp status pre and post treatment was assessed according to local clinical practice protocol. A 14-day concomitant therapy (amoxicillin 1 g, clarithromycin 500 mg and metronidazole 500 mg plus omeprazole 20 mg, all drugs administered twice daily) was prescribed. Adherence to therapy and adverse events were assessed by personal interview. Results: 112 patients were enrolled. Mean age was 46.7 ± 16.1 years. Main indication for treatment was non-investigated dyspepsia (83%). Hp eradication was achieved in 100 of the 112 patients. Eradication rates were 89.3% (95% CI: 81.7–94.1) by intention-to-treat (ITT) analysis and 91.7% (95% CI; 84.6–95.9) per protocol (PP). No major side effects were reported; 104 (92.8%) patients complete the treatment. Forty-seven patients (42%) complained of mild side effects (metallic taste, nausea). Low adherence to treatment (p = 0.004) and significant adverse events (p = 0.004) were the variables associated with treatment failure. Conclusions: In primary care, a 14-day concomitant therapy is highly effective and well tolerated. | en |
dc.format.extent | 8 | ca |
dc.language.iso | eng | ca |
dc.publisher | MDPI | ca |
dc.relation.ispartof | Journal of Clinical Medicine | ca |
dc.relation.ispartofseries | 9;8 | |
dc.rights | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject.other | Helicobacter | ca |
dc.subject.other | Eradicació | ca |
dc.subject.other | Tractament | ca |
dc.subject.other | Concomitant | ca |
dc.subject.other | Atenció primària | ca |
dc.subject.other | Multicèntric | ca |
dc.subject.other | Helicobacter | es |
dc.subject.other | Erradicación | es |
dc.subject.other | Tratamiento | es |
dc.subject.other | Concomitante | es |
dc.subject.other | Atención primaria | es |
dc.subject.other | Multicéntrico | es |
dc.subject.other | Helicobacter | en |
dc.subject.other | Eradication | en |
dc.subject.other | Treatment | en |
dc.subject.other | Concomitant | en |
dc.subject.other | Primary care | en |
dc.subject.other | Multicenter | en |
dc.title | High effectiveness of a 14-day concomitant therapy for helicobacter pylori treatment in primary care. An observational multicenter study | en |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 61 | ca |
dc.subject.udc | 616.3 | ca |
dc.identifier.doi | https://dx.doi.org/10.3390/jcm9082410 | ca |
Ficheros en el ítem
Este ítem aparece en la(s) siguiente(s) colección(ones)
-
Ciències de la Salut [740]