High effectiveness of a 14-day concomitant therapy for helicobacter pylori treatment in primary care. An observational multicenter study
Author
Olmedo, Llum
Azagra, Rafael
Aguyé, Amada
Pascual, Marta
Calvet, Xavier
Gené Tous, Emilio Miguel
Publication date
2020ISSN
2077-0383
Abstract
Background: The current cure rates with triple therapy combining a proton-pump inhibitor, amoxicillin and clarithromycin are unacceptably low. Aims: To evaluate the efficacy of a 14-day concomitant therapy as an empirical first-line treatment for curing Helicobacter pylori (Hp) infection in primary care. Methods: Patients from six primary care centers in Catalonia -Spain- were included consecutively. Hp status pre and post treatment was assessed according to local clinical practice protocol. A 14-day concomitant therapy (amoxicillin 1 g, clarithromycin 500 mg and metronidazole 500 mg plus omeprazole 20 mg, all drugs administered twice daily) was prescribed. Adherence to therapy and adverse events were assessed by personal interview. Results: 112 patients were enrolled. Mean age was 46.7 ± 16.1 years. Main indication for treatment was non-investigated dyspepsia (83%). Hp eradication was achieved in 100 of the 112 patients. Eradication rates were 89.3% (95% CI: 81.7–94.1) by intention-to-treat (ITT) analysis and 91.7% (95% CI; 84.6–95.9) per protocol (PP). No major side effects were reported; 104 (92.8%) patients complete the treatment. Forty-seven patients (42%) complained of mild side effects (metallic taste, nausea). Low adherence to treatment (p = 0.004) and significant adverse events (p = 0.004) were the variables associated with treatment failure. Conclusions: In primary care, a 14-day concomitant therapy is highly effective and well tolerated.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
61 - Medical sciences
616.3 - Pathology of the digestive system. Complaints of the alimentary canal
Keywords
Helicobacter
Eradicació
Tractament
Concomitant
Atenció primària
Multicèntric
Helicobacter
Erradicación
Tratamiento
Concomitante
Atención primaria
Multicéntrico
Helicobacter
Eradication
Treatment
Concomitant
Primary care
Multicenter
Pages
8
Publisher
MDPI
Collection
9; 8
Is part of
Journal of Clinical Medicine
Citation
Olmedo, Llum; Azagra, Rafael; Aguyé, Amada [et al.]. High effectiveness of a 14-day concomitant therapy for helicobacter pylori treatment in primary care. An observational multicenter study. Journal of Clinical Medicine, 2020, 9(8), 2410. Disponible en: <https://www.mdpi.com/2077-0383/9/8/2410>. Fecha de acceso: 21 sep. 2021. DOI: 10.3390/jcm9082410
This item appears in the following Collection(s)
- Ciències de la Salut [740]
Rights
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/