High effectiveness of a 14-day concomitant therapy for helicobacter pylori treatment in primary care. An observational multicenter study
Autor/a
Olmedo, Llum
Azagra, Rafael
Aguyé, Amada
Pascual, Marta
Calvet, Xavier
Gené Tous, Emilio Miguel
Data de publicació
2020ISSN
2077-0383
Resum
Background: The current cure rates with triple therapy combining a proton-pump inhibitor, amoxicillin and clarithromycin are unacceptably low. Aims: To evaluate the efficacy of a 14-day concomitant therapy as an empirical first-line treatment for curing Helicobacter pylori (Hp) infection in primary care. Methods: Patients from six primary care centers in Catalonia -Spain- were included consecutively. Hp status pre and post treatment was assessed according to local clinical practice protocol. A 14-day concomitant therapy (amoxicillin 1 g, clarithromycin 500 mg and metronidazole 500 mg plus omeprazole 20 mg, all drugs administered twice daily) was prescribed. Adherence to therapy and adverse events were assessed by personal interview. Results: 112 patients were enrolled. Mean age was 46.7 ± 16.1 years. Main indication for treatment was non-investigated dyspepsia (83%). Hp eradication was achieved in 100 of the 112 patients. Eradication rates were 89.3% (95% CI: 81.7–94.1) by intention-to-treat (ITT) analysis and 91.7% (95% CI; 84.6–95.9) per protocol (PP). No major side effects were reported; 104 (92.8%) patients complete the treatment. Forty-seven patients (42%) complained of mild side effects (metallic taste, nausea). Low adherence to treatment (p = 0.004) and significant adverse events (p = 0.004) were the variables associated with treatment failure. Conclusions: In primary care, a 14-day concomitant therapy is highly effective and well tolerated.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
61 - Medicina
616.3 - Patologia de l'aparell digestiu. Odontologia
Paraules clau
Helicobacter
Eradicació
Tractament
Concomitant
Atenció primària
Multicèntric
Helicobacter
Erradicación
Tratamiento
Concomitante
Atención primaria
Multicéntrico
Helicobacter
Eradication
Treatment
Concomitant
Primary care
Multicenter
Pàgines
8
Publicat per
MDPI
Col·lecció
9; 8
Publicat a
Journal of Clinical Medicine
Citació
Olmedo, Llum; Azagra, Rafael; Aguyé, Amada [et al.]. High effectiveness of a 14-day concomitant therapy for helicobacter pylori treatment in primary care. An observational multicenter study. Journal of Clinical Medicine, 2020, 9(8), 2410. Disponible en: <https://www.mdpi.com/2077-0383/9/8/2410>. Fecha de acceso: 21 sep. 2021. DOI: 10.3390/jcm9082410
Aquest element apareix en la col·lecció o col·leccions següent(s)
- Ciències de la Salut [740]
Drets
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Excepte que s'indiqui una altra cosa, la llicència de l'ítem es descriu com https://creativecommons.org/licenses/by/4.0/