Biofunctionalization strategies on tantalum-based materials for osseointegrative applications
Autor/a
Mas Moruno, Carlos
Garrido, Beatriz
Rodriguez, Daniel
Rupérez de Gracia, Elisa
Gil Mur, Francisco Javier
Data de publicació
2015ISSN
1573-4838
Resum
The use of tantalum as biomaterial for orthopedic applications is gaining considerable attention in the clinical practice because it presents an excellent chemical stability, body fluid resistance, biocompatibility, and it is more osteoconductive than titanium or cobalt-chromium alloys. Nonetheless, metallic biomaterials are commonly bioinert and may not provide fast and long-lasting interactions with surrounding tissues. The use of short cell adhesive peptides derived from the extracellular matrix has shown to improve cell adhesion and accelerate the implant’s biointegration in vivo. However, this strategy has been rarely applied to tantalum materials. In this work, we have studied two immobilization strategies (physical adsorption and covalent binding via silanization) to functionalize tantalum surfaces with a cell adhesive RGD peptide. Surfaces were used untreated or activated with either HNO3 or UV/ozone treatments. The process of biofunctionalization was characterized by means of physicochemical and biological methods. Physisorption of the RGD peptide on control and HNO3-treated tantalum surfaces significantly enhanced the attachment and spreading of osteoblast-like cells; however, no effect on cell adhesion was observed in ozone-treated samples. This effect was attributed to the inefficient binding of the peptide on these highly hydrophilic surfaces, as evidenced by contact angle measurements and X-ray photoelectron spectroscopy. In contrast, activation of tantalum with UV/ozone proved to be the most efficient method to support silanization and subsequent peptide attachment, displaying the highest values of cell adhesion. This study demonstrates that both physical adsorption and silanization are feasible methods to immobilize peptides onto tantalum-based materials, providing them with superior bioactivity.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
61 - Medicina
620 - Assaig de materials. Materials comercials. Economia de l'energia
Paraules clau
Materials biomèdics
Ortopèdia
Titani
Cobalt
Crom
Implants artificials
Biocompatibilitat
Materiales biomédicos
Ortopedia
Titanio
Cobalto
Cromo
Implantes artificiales
Biocompatibilidad
Biomedical materials
Orthopedics
Titanium
Cobalt
Chrome
Artificial implants
Biocompatibility
Pàgines
12
Publicat per
Springer Nature
Col·lecció
26;
Publicat a
Journal of Materials Science: Materials in Medicine
Citació
Mas-Moruno, Carlos; Garrido, Beatriz; Rodriguez, Daniel [et al.]. Biofunctionalization strategies on tantalum-based materials for osseointegrative applications. Journal of Materials Science: Materials in Medicine, 2015, 26, 109. Disponible en: <https://link.springer.com/article/10.1007/s10856-015-5445-z>. Fecha de acceso: 14 may. 2021. DOI: 10.1007/s10856-015-5445-z
Número de l'acord de la subvenció
info:eu-repo/grantAgreement/MINECO/6PN/MAT2012-30706
info:eu-repo/grantAgreement/EC/FP7/321985
Aquest element apareix en la col·lecció o col·leccions següent(s)
- Ciències de la Salut [740]
Drets
This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
Excepte que s'indiqui una altra cosa, la llicència de l'ítem es descriu com https://creativecommons.org/licenses/by-nc-nd/4.0/