Current challenges for targeting brown fat thermogenesis to combat obesity
Author
Yoneshiro, Takeshi
Rodríguez-Rodríguez, Rosalía
Johannes Betz, Matthias
Rensen, Patrick C. N.
Publication date
2020-10-27ISSN
1664-2392
Abstract
Just over a decade has passed since metabolically active brown adipose tissue (BAT) was unequivocally identified in healthy adult humans. Since then, researchers have provided evidence of expression of the thermogenic molecule uncoupling protein 1 (UCP1) in human BAT, as well as its energy dissipating capacity. Additionally, clinical cross-sectional analysis suggested that a decline in BAT activity with aging, as judged from [18F]FDG-PET/CT, coincides with the development of obesity and insulin resistance. These major observations provided a rationale to investigate BAT as a potential target for preventing obesity. Indeed, several studies have demonstrated that cold exposure and adrenomimetic agents strongly activate BAT thermogenesis, and thus energy expenditure in humans. However, the extent to which stimulating BAT thermogenesis decreases adiposity in humans remains unclear. Moreover, therapeutic strategies aimed at general stimulation of the sympathetic nervous system (SNS) and adrenergic receptors involved may not be applicable for obese and diabetic patients, because of potential negative side-effects on cardiovascular function.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
61 - Medical sciences
616.4 - Pathology of the lymphatic system, haemopoietic (haematopoietic) organs, endocrines
Keywords
Teixit adipós
Metabolisme
Obesitat
Diabetis
Tejido adiposo
Metabolismo
Obesidad
Diabetes
Adipose tissue
Metabolism
Obesity
Diabetes
Pages
4
Publisher
Frontiers Media S.A.
Collection
11;
Is part of
Frontiers in Endocrinology
Citation
Yoneshiro, Takeshi; Rodríguez-Rodríguez, Rosalía; Johannes Betz, Matthias [et al.]. Current challenges for targeting brown fat thermogenesis to combat obesity. Frontiers in Endocrinology, 2020, 11, e.600341. Disponible en: <https://www.frontiersin.org/articles/10.3389/fendo.2020.600341/full>. Fecha de acceso: 18 dic. 2020. DOI: /10.3389/fendo.2020.600341
Grant agreement number
info:eu-repo/grantAgreement/ES/2PE/SAF2017-82813-C3-3R
This item appears in the following Collection(s)
- Ciències de la Salut [740]
Rights
© 2020 Yoneshiro, Rodríguez-Rodríguez, Betz and Rensen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/