Current challenges for targeting brown fat thermogenesis to combat obesity
Autor/a
Yoneshiro, Takeshi
Rodríguez-Rodríguez, Rosalía
Johannes Betz, Matthias
Rensen, Patrick C. N.
Fecha de publicación
2020-10-27ISSN
1664-2392
Resumen
Just over a decade has passed since metabolically active brown adipose tissue (BAT) was unequivocally identified in healthy adult humans. Since then, researchers have provided evidence of expression of the thermogenic molecule uncoupling protein 1 (UCP1) in human BAT, as well as its energy dissipating capacity. Additionally, clinical cross-sectional analysis suggested that a decline in BAT activity with aging, as judged from [18F]FDG-PET/CT, coincides with the development of obesity and insulin resistance. These major observations provided a rationale to investigate BAT as a potential target for preventing obesity. Indeed, several studies have demonstrated that cold exposure and adrenomimetic agents strongly activate BAT thermogenesis, and thus energy expenditure in humans. However, the extent to which stimulating BAT thermogenesis decreases adiposity in humans remains unclear. Moreover, therapeutic strategies aimed at general stimulation of the sympathetic nervous system (SNS) and adrenergic receptors involved may not be applicable for obese and diabetic patients, because of potential negative side-effects on cardiovascular function.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
English
Materias (CDU)
61 - Medicina
616.4 - Patología del sistema linfático, órganos hematopoyéticos, endocrinos
Palabras clave
Teixit adipós
Metabolisme
Obesitat
Diabetis
Tejido adiposo
Metabolismo
Obesidad
Diabetes
Adipose tissue
Metabolism
Obesity
Diabetes
Páginas
4
Publicado por
Frontiers Media S.A.
Colección
11;
Publicado en
Frontiers in Endocrinology
Citación
Yoneshiro, Takeshi; Rodríguez-Rodríguez, Rosalía; Johannes Betz, Matthias [et al.]. Current challenges for targeting brown fat thermogenesis to combat obesity. Frontiers in Endocrinology, 2020, 11, e.600341. Disponible en: <https://www.frontiersin.org/articles/10.3389/fendo.2020.600341/full>. Fecha de acceso: 18 dic. 2020. DOI: /10.3389/fendo.2020.600341
Número del acuerdo de la subvención
info:eu-repo/grantAgreement/ES/2PE/SAF2017-82813-C3-3R
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Derechos
© 2020 Yoneshiro, Rodríguez-Rodríguez, Betz and Rensen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Excepto si se señala otra cosa, la licencia del ítem se describe como https://creativecommons.org/licenses/by/4.0/