Pomace olive oil concentrated in triterpenic acids restores vascular function, glucose tolerance and obesity progression in mice
Autor/a
Claro-Cala, Carmen Maria
Quintela, Jose Carlos
Pérez-Montero, Marta
Miñano, Javier
Alvarez de Sotomayor, María
Dolores Herrera, María
Rodríguez-Rodríguez, Rosalía
Fecha de publicación
2020-01ISSN
2072-6643
Resumen
Pomace olive oil, an olive oil sub-product, is a promising source of bioactive triterpenoids such as oleanolic acid and maslinic acid. Considering the vascular actions of pomace olive oil and the potential effects of the isolated oleanolic acid on metabolic complications of obesity, this study investigates for the first time the dietary intervention with a pomace olive oil with high concentrations of the triterpenic acids (POCTA), oleanolic and maslinic acid, during diet-induced obesity in mice. The results demonstrate that obese mice, when switched to a POCTA-diet for 10 weeks, show a substantial reduction of body weight, insulin resistance, adipose tissue inflammation, and particularly, improvement of vascular function despite high caloric intake. This study reveals the potential of a functional food based on pomace olive oil and its triterpenic fraction against obesity progression. Our data also contribute to understanding the health-promoting effects attributable to the Mediterranean diet.
Tipo de documento
Artículo
Versión del documento
Versión aceptada
Lengua
English
Materias (CDU)
61 - Medicina
Palabras clave
Obesitat
Metabolisme
Glucosa
Dieta
Insulinoresistència
Obesity
Metabolism
Glucose
Diet
Insulin resistance
Obesidad
Metabolismo
Glucosa
Dieta
Insulinorresistencia
Páginas
14
Publicado por
MDPI
Colección
12; 2
Publicado en
Nutrients
Citación
Claro-Cala, Carmen Maria; Quintela, Jose Carlos; Pérez-Montero, Marta [et al.]. Pomace olive oil concentrated in triterpenic acids restores vascular function, glucose tolerance and obesity progression in mice. Nutrients, 2020, vol. 12, núm. 2, e323. Disponible en: <https://www.mdpi.com/2072-6643/12/2/323>. Fecha de acceso: 1 mar. 2020. DOI: 10.3390/nu12020323
Número del acuerdo de la subvención
info:eu-repo/grantAgreement/ES/2PE/SAF2017-82813-C3-3-R
info:eu-repo/grantAgreement/ES/2PE/PCI2018-092997/AEI
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Derechos
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