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dc.contributor.authorClaro-Cala, Carmen Maria
dc.contributor.authorQuintela, Jose Carlos
dc.contributor.authorPérez-Montero, Marta
dc.contributor.authorMiñano, Javier
dc.contributor.authorAlvarez de Sotomayor, María
dc.contributor.authorDolores Herrera, María
dc.contributor.authorRodríguez-Rodríguez, Rosalía
dc.date.accessioned2020-03-01T14:59:59Z
dc.date.available2020-03-01T14:59:59Z
dc.date.issued2020-01
dc.identifier.citationClaro-Cala, Carmen Maria; Quintela, Jose Carlos; Pérez-Montero, Marta [et al.]. Pomace olive oil concentrated in triterpenic acids restores vascular function, glucose tolerance and obesity progression in mice. Nutrients, 2020, vol. 12, núm. 2, e323. Disponible en: <https://www.mdpi.com/2072-6643/12/2/323>. Fecha de acceso: 1 mar. 2020. DOI: 10.3390/nu12020323ca
dc.identifier.issn2072-6643ca
dc.identifier.urihttp://hdl.handle.net/20.500.12328/1471
dc.description.abstractPomace olive oil, an olive oil sub-product, is a promising source of bioactive triterpenoids such as oleanolic acid and maslinic acid. Considering the vascular actions of pomace olive oil and the potential effects of the isolated oleanolic acid on metabolic complications of obesity, this study investigates for the first time the dietary intervention with a pomace olive oil with high concentrations of the triterpenic acids (POCTA), oleanolic and maslinic acid, during diet-induced obesity in mice. The results demonstrate that obese mice, when switched to a POCTA-diet for 10 weeks, show a substantial reduction of body weight, insulin resistance, adipose tissue inflammation, and particularly, improvement of vascular function despite high caloric intake. This study reveals the potential of a functional food based on pomace olive oil and its triterpenic fraction against obesity progression. Our data also contribute to understanding the health-promoting effects attributable to the Mediterranean diet.ca
dc.format.extent14ca
dc.language.isoengca
dc.publisherMDPIca
dc.relation.ispartofNutrientsca
dc.relation.ispartofseries12;2
dc.rights© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).ca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.otherObesitatca
dc.subject.otherMetabolisme
dc.subject.otherGlucosa
dc.subject.otherDieta
dc.subject.otherInsulinoresistència
dc.subject.otherObesity
dc.subject.otherMetabolism
dc.subject.otherGlucose
dc.subject.otherDiet
dc.subject.otherInsulin resistance
dc.subject.otherObesidad
dc.subject.otherMetabolismo
dc.subject.otherGlucosa
dc.subject.otherDieta
dc.subject.otherInsulinorresistencia
dc.titlePomace olive oil concentrated in triterpenic acids restores vascular function, glucose tolerance and obesity progression in miceca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/acceptedVersionca
dc.embargo.termscapca
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/2PE/SAF2017-82813-C3-3-Rca
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/2PE/PCI2018-092997/AEIca
dc.subject.udc61ca
dc.identifier.doihttps://dx.doi.org/10.3390/nu12020323ca


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© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/