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    • Psychometric properties of the spanish version of the Jefferson Scale of Empathy: making sense of the total score through a second order confirmatory factor analysis 

      Ferreira-Valente, Alexandra; Costa, Patrício; Elorduy Hernández-Vaquero, Marta; Virumbrales Cancio, Montserrat; Costa, Manuel J.; Palés, Jorge (BMC Medical Education, 2016-09-19)
      Background: Empathy is a key aspect of the physician-patient interactions. The Jefferson Scale of Empathy (JSE) is one of the most used empathy measures of medical students. The development of cross-cultural ...

    • Gender differences in labour losses associated with smoking-related mortality 

      Oliva Moreno, Juan; Trapero Bertran, Marta; Peña-Longobardo, Luz María (International Journal of Environmental Research and Public Health, 2019-09-28)
      The aim of this paper was to estimate the number of premature deaths, years of potential productive life lost (YPPLL) and labour losses attributable to tobacco smoking due to premature death by gender ...

    • Ultrasensitive photonic microsystem enabling sub-micrometric monitoring of arterial oscillations for advanced cardiovascular studies 

      Rodríguez-Rodríguez, Rosalía; Nils Ackermann, Tobias; Plaza, Jose Antonio; Simonsen, Ulf; Matchkov, Vladimir; Llobera, Andreu; Munoz-Berbel, Xavier (Frontiers in Physiology, 2019-07-23)
      Cardiovascular diseases are the first cause of death globally. Their early diagnosis requires ultrasensitive tools enabling the detection of minor structural and functional alterations in small arteries. ...

    • Mevalonate pathway activity as a determinant of radiation sensitivity in head and neck cancer 

      Ricco Pacheco, Natalia; Flor, Amy; Wolfgeher, Donald; Efimova, Elena V.; Ramamurthy, Aishwarya; Appelbe, Oliver K.; Brinkman, Jacqueline; Truman, Andrew W.; Spiotto, Michael T.; Kron, Stephen J. (Molecular Oncology, 2019-06-21)
      Radioresistance is a major hurdle in the treatment of head and neck squamous cell carcinoma (HNSCC). Here, we report that concomitant treatment of HNSCCs with radiotherapy and mevalonate pathway inhibitors ...

    • The quantitative changes in the yeast Hsp70 and Hsp90 interactomes upon DNA damage 

      Truman, Andrew W.; Kristjansdottir, Kolbrun; Wolfgeher, Donald; Ricco Pacheco, Natalia; Mayampurath, Anoop; Volchenboum, Samuel L.; Clotet Erra, Josep; Kron, Stephen J. (Data in Brief, 2015-03)
      The molecular chaperones Hsp70 and Hsp90 participate in many important cellular processes, including how cells respond to DNA damage. Here we show the results of applied quantitative affinity-purification ...

    • Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders 

      Mingorance, Carmen; Rodríguez-Rodríguez, Rosalía; Justo, María Luisa; Álvarez de Sotomayor, María; Dolores Herrera, María (Vascular Health and Risk Management, 2011-03-28)
      Acetyl-L-carnitine (ALC) and propionyl-L-carnitine (PLC) are two naturally occurring carnitine derivates formed by carnitine acetyltransferase. The beneficial cardiovascular effects of ALC and PLC have ...

    • Characterization of ferrofluid-based stimuli-responsive elastomers 

      De Pedro, Sandra; Muñoz-Berbel, Xavier; Rodríguez-Rodríguez, Rosalía; Sort, Jordi; Plaza, Jose Antonio; Brugger, Juergen; Llobera, Andreu; Cadarso, Victor J. (Frontiers in Mechanical Engineering, 2016-12-12)
      Stimuli-responsive materials undergo physicochemical and/or structural changes when a specific actuation is applied. They are heterogeneous composites, consisting of a non-responsive matrix where ...

    • Effectiveness of a specific manual approach to the suboccipital region in patients with chronic mechanical neck pain and rotation deficit in the upper cervical spine: study protocol for a randomized controlled trial 

      González Rueda, Vanessa; López de Celis, Carlos; Barra-López, Martín Eusebio; Carrasco Uribarren, Andoni; Castillo Tomás, Sara; Hidalgo-García, César (BMC Musculoskeletal Disorders, 2017-09-05)
      This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and ...

    • High-flow nasal cannula to prevent postextubation respiratory failure in high-risk non-hypercapnic patients: a randomized multicenter trial 

      Fernandez, Rafael; Subirà Cuyàs, Carles; Frutos‑Vivar, Fernando; Rialp, Gemma; Laborda, Cesar; Masclans, Joan Ramon; Lesmes, Amanda; Panadero, Luna; Hernandez, Gonzalo (Annals of Intensive Care, 2017-05-02)
      Background: Extubation failure is associated with increased morbidity and mortality, but cannot be safely predicted or avoided. High-flow nasal cannula (HFNC) prevents postextubation respiratory failure ...

    • Automatic detection of ventilatory modes during invasive mechanical ventilation 

      Murias, Gastón; Montanyà, Jaume; Chacón, Encarna; Estruga, Anna; Subirà Cuyàs, Carles; Fernández Fernández, Rafael; Sales, Bernat; De Haro, Candelaria; López-Aguilar, Josefina; Lucangelo, Umberto; Villar, Jesús; Kacmarek, Robert M.; Blanch, Lluís (Critical Care, 2016-08-14)
      Background: Expert systems can help alleviate problems related to the shortage of human resources in critical care, offering expert advice in complex situations. Expert systems use contextual information ...

    • Effectiveness of a Surgery Admission Unit for patients undergoing major elective surgery in a tertiary university hospital 

      Ortiga Fontgivell, Berta; Capdevila, Cristina; Salazar Soler, Albert; Viso, M.F.; Bartolomé Sarvisé, Carlos; Corbella Virós, Xavier (BMC Health Services Research, 2010-01-22)
      Background: The increasing demand on hospitalisation, either due to elective activity from the waiting lists or due to emergency admissions coming from the Emergency Department (ED), requires looking ...

    • ALCAM shedding at the invasive front of the tumor is a marker of myometrial infiltration and promotes invasion in endometrioid endometrial cancer 

      Devis, Laura; Martinez-Garcia, Elena; Moiola, Cristian P.; Quiles Pérez, María Teresa; Arbós Vilà, Maria Antonia; Vasilica Stirbat, Tomita; Brochard-Wyart, Françoise; García, Ángel; Alonso-Alconada, Lorena; Abal, Miguel; Diaz-Feijoo, Berta; Thomas, William; Dufour, Sylvie; Mancebo, Gemma; Alameda, Francesc; Reventós, Jaume; Gil-Moreno, Antonio; Colas, Eva (Oncotarget, 2018-03-30)
      Endometrial cancer (EC) is the sixth deadliest cancer in women. The depth of myometrial invasion is one of the most important prognostic factors, being directly associated with tumor recurrence and ...

    • Standardizing admission and discharge processes to improve patient flow: a cross sectional study 

      Ortiga Fontgivell, Berta; Salazar Soler, Albert; Jovell Fernández, Albert; Escarrabill, Joan; Marca, Guillem; Corbella Virós, Xavier (BMC Health Services Research, 2012-06-28)
      Background: The aim of this study was to evaluate how hospital capacity was managed focusing on standardizing the admission and discharge processes. Methods: This study was set in a 900-bed university ...

    • The impact of KRAS mutations on VEGF-A production and tumour vascular network 

      Figueras, Agnès; Arbós Vilà, Maria Antonia; Quiles Pérez, María Teresa; Viñals, Francesc; Germà, Josep Ramón; Capellà, Gabriel (BMC Cancer, 2013-03-18)
      Background: The malignant potential of tumour cells may be influenced by the molecular nature of KRAS mutations being codon 13 mutations less aggressive than codon 12 ones. Their metabolic profile is ...

    • Impaired cerebral autoregulation is associated with brain dysfunction in patients with sepsis 

      Crippa, Ilaria Alice; Subirà Cuyàs, Carles; Vincent, Jean-Louis; Fernández Fernández, Rafael; Cano Hernandez, Silvia; Zama Cavicchi, Federica; Creteur, Jacques; Taccone, Fabio Silvio (Critical Care, 2018-12-04)
      Background: Sepsis-associated brain dysfunction (SABD) is associated with high morbidity and mortality. The pathophysiology of SABD is multifactorial. One hypothesis is that impaired cerebral autoregulation ...

    • Predicting patient-ventilator asynchronies with hidden markov models 

      Marchuk, Yaroslav; Magrans, Rudys; Sales, Bernat; Montanyà, Jaume; López-Aguilar, Josefina; De Haro, Candelaria; Gomà Fernández, Gemma; Subirà Cuyàs, Carles; Fernández Fernández, Rafael; Kacmarek, Robert M.; Blanch, Lluís (Scientific Reports, 2018-12-04)
      In mechanical ventilation, it is paramount to ensure the patient’s ventilatory demand is met while minimizing asynchronies. We aimed to develop a model to predict the likelihood of asynchronies occurring. ...

    • High red blood cell distribution width as a marker of hospital mortality after ICU discharge: a cohort study 

      Fernandez, Rafael; Cano Hernandez, Silvia; Catalan, Ignacio; Rubio Sanchiz, Olga; Subirà Cuyàs, Carles; Masclans, Jaume; Rognoni, Gina; Ventura, Lara; Macharete, Caroline; Winfield, Len; Alcoverro, Josep Mª. (Journal of Intensive Care, 2018-11-16)
      Background: High red blood cell distribution width (RDW) is associated with worse outcome in diverse scenarios, including in critical illness. The Sabadell score (SS) predicts in-hospital survival after ...

    • Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance 

      Contreras, Cristina; González-García, Ismael; Martínez-Sánchez, Noelia; Seoane-Collazo, Patricia; Jacas i Mateu, Jordi; Morgan, Donald A.; Serra, Dolors; Gallego, Rosalía; Gonzalez, Francisco; Casals i Farré, Núria; Nogueiras, Rubén; Rahmouni, Kamal; Diéguez, Carlos; López, Miguel (Cell Reports, 2014-10)
      Hypothalamic endoplasmic reticulum (ER) stress is a key mechanism leading to obesity. Here, we demonstrate that ceramides induce lipotoxicity and hypothalamic ER stress, leading to sympathetic inhibition, ...

    • CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity 

      Rodríguez-Rodríguez, Rosalía; Miralpeix Monclús, Cristina; Fosch, Anna; Pozo Ariza, Macarena; Calderón-Domínguez, María; Perpinyà, Xavier; Vellvehí, Miquel; López, Miguel; Herrero Rodríguez, Laura; Serra, Dolors; Casals i Farré, Núria (Molecular Metabolism, 2019-01)
      Objective: Carnitine palmitoyltransferase 1C (CPT1C) is implicated in central regulation of energy homeostasis. Our aim was to investigate whether CPT1C in the ventromedial nucleus of the hypothalamus ...

    • Astrocytes and oligodendrocytes in grey and white matter regions of the brain metabolize fatty acids 

      Hofmann, Kristina; Rodríguez-Rodríguez, Rosalía; Gaebler, Anne; Casals i Farré, Núria; Scheller, Anja; Kuerschner, Lars (Scientific Reports, 2017-09-07)
      The grey and white matter regions of the mammalian brain consist of both neurons and neuroglial cells. Among the neuroglia, the two macroglia oligodendrocytes and astrocytes are the most abundant cell ...