Ciències de la Salut: Agregados recientemente
Mostrando ítems 781-800 de 979
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Implication between genetic variants from APOA5 and ZPR1 and NAFLD severity in patients with hypertriglyceridemia
(Nutrients, 2021)Background: Lipid metabolism disorders, especially hypertriglyceridemia (HTG), are risk factors for non-alcoholic fatty liver disease (NAFLD). However, the association between genetic factors related ... -
Smartphone and tablet usage during COVID-19 pandemic confinement in children under 48 months in Barcelona (Spain)
(Healthcare, 2021)Background: Total lockdown due to COVID-19 pandemic might have potentially increased screen time in children. This study aims to describe the smartphone and tablets usage in children under 48 months ... -
Pragmatic, open-label, single-center, randomized, phase II clinical trial to evaluate the efficacy and safety of methylprednisolone pulses and tacrolimus in patients with severe pneumonia secondary to COVID-19: the TACROVID trial protocol
(Contemporary Clinical Trials Communications, 2021-03)Introduction: Some COVID-19 patients evolve to severe lung injury and systemic hyperinflammatory syndrome triggered by both the coronavirus infection and the subsequent host-immune response. Accordingly, ... -
Genomic and serologic characterization ofenterovirus A71 brainstem encephalitis
(Neurology: Neuroimmunology & Neuroinflammation, 2020)Objective: In 2016, Catalonia experienced a pediatric brainstem encephalitis outbreak caused by enterovirus A71 (EV-A71). Conventional testing identified EV in the periphery but rarely in CSF. Metagenomic ... -
Pneumonia in children admitted to the national referral hospital in Bhutan: a prospective cohort study
(International Journal of Infectious Diseases, 2020-06)Objectives: The study aim was to describe the etiological profile and clinical characteristics of pneumonia among children hospitalized in Thimphu, Bhutan. Methods: This prospective study enrolled ... -
Pneumococcal nasopharyngeal carriageamong Bhutanese children hospitalizedwith clinical pneumonia: serotypes andviral co-infection
(BMC Infectious Diseases, 2020-12)Background: Pneumococcal nasopharyngeal colonization (PNC) generally precedes pneumococcal disease. The purpose of this study was to determine the prevalence of PNC and to identify the pneumococcal ... -
Pneumococcal serotypes in children, clinical presentation and antimicrobial susceptibility in the PCV13 era
(Epidemiology and Infection, 2020-11)The aim was to analyse invasive pneumococcal disease (IPD) serotypes in children aged ⩽17 years according to clinical presentation and antimicrobial susceptibility. We conducted a prospective study ... -
Impact of the 13-valent conjugated pneumococcal vaccine on the direct costs of invasive pneumococcal disease requiring hospital admission in children aged < 5 years: a prospective study
(Vaccines, 2020)The lack of invasive pneumococcal disease (IPD) cost studies may underestimate the eect of pneumococcal polysaccharide conjugated vaccines (PCV). The objective of this study was to estimate the direct ... -
Rapid identification, capsular typing and molecular characterization of streptococcus pneumoniae by using whole genome nanopore sequencing
(BMC Microbiology, 2020)Background: Whole genome sequencing has emerged as a useful tool for identification and molecular characterization of pathogens. MinION (Oxford Nanopore) is a real-time third generation sequencer whose ... -
Reduction of direct health costs associated with pertussis vaccination with acellular vaccines in children aged 0–9 years with pertussis in Catalonia (Spain)
(PharmacoEconomics - Open, 2019)Objectives: The aim of this study was to assess direct health costs in children with pertussis aged 0–9 years who were vaccinated, partially vaccinated, and unvaccinated during childhood, and to assess ... -
Cerebrospinal fluid neopterin as a biomarker of neuroinflammatory diseases
(Scientific Reports, 2020)The elevation of neopterin in cerebrospinal fluid (CSF) has been reported in several neuroinflammatory disorders. However, it is not expected that neopterin alone can discriminate among different ... -
Validation of a loop-mediated isothermal amplification assay for rapid diagnosis of invasive pneumococcal disease
(Frontiers in Cellular and Infection Microbiology, 2020-03-24)Current molecular PCR-based techniques used for detecting Streptococcus pneumoniae, the causative pathogen of invasive pneumococcal disease (IPD), are accurate but have a run time of several hours. We ... -
Serotype and clonal distribution dynamics of invasive pneumococcal strains after PCV13 introduction (2011-2016): surveillance data from 23 sites in Catalonia, Spain
(PLoS One, 2020-02)Background: The objective of this study is to describe incidence and shifts of serotype and clonal distribution of invasive Streptococcus pneumoniae strains in four different age groups (<5 years, 5–17 ... -
Biological roles and delivery strategies for ions to promote osteogenic induction
(Frontiers in Cell and Developmental Biology, 2021-01-14)Bone is the most studied tissue in the field of tissue regeneration. Even though it has intrinsic capability to regenerate upon injury, several pathologies and injuries could hamper the highly orchestrated ... -
Blood test dynamics in hospitalized COVID-19 patients: Potential utility of D-dimer for pulmonary embolism diagnosis
(PLoS One, 2020-12-28)Background: A higher incidence of thrombotic events, mainly pulmonary embolism (PE), has been reported in hospitalized patients with COVID-19. The main objective was to assess clinical and laboratory ... -
Sonochemical coating of Prussian Blue for the production of smart bacterial-sensing hospital textiles
(Ultrasonics Sonochemistry, 2021-01)In healthcare facilities, environmental microbes are responsible for numerous infections leading to patient’s health complications and even death. The detection of the pathogens present on contaminated ... -
Editorial: current challenges for targeting brown fat thermogenesis to combat obesity
(Frontiers in Endocrinology, 2020-10-27)Just over a decade has passed since metabolically active brown adipose tissue (BAT) was unequivocally identified in healthy adult humans. Since then, researchers have provided evidence of expression of ... -
SIRT3 deficiency exacerbates fatty liver by attenuating the HIF1α-LIPIN 1 pathway and increasing CD36 through Nrf2
(Cell Communication and Signaling18;147, 2020-09-10)Background: Deficiency of mitochondrial sirtuin 3 (SIRT3), a NAD+-dependent protein deacetylase that maintains redox status and lipid homeostasis, contributes to hepatic steatosis. In this study, we ... -
Early short-term postoperative mechanical failures of current ceramic-on-ceramic bearing total hip arthroplasties
(Materials, 2020)Although ceramic-on-ceramic (CoC) bearings have been shown to produce the smallest amount of wear volume in vitro as well as in vivo studies when used for total hip arthroplasties (THA), concerns about ... -
The return of malonyl-CoA to the brain: cognition and other stories
(Progress in Lipid Research, 2021-01)Nutrients, hormones and the energy sensor AMP-activated protein kinase (AMPK) tightly regulate the intracel-lular levels of the metabolic intermediary malonyl-CoA, which is a precursor of fatty ...