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    • The effectiveness of extracorporeal shock wave therapy to reduce lower limb spasticity in stroke patients: a systematic review and meta-analysis 

      Cabanas-Valdés, Rosa; Calvo-Sanz, Jordi; Urrùtia, Gerard; Serra-Llobet, Pol; Albert, Pérez-Bellmunt; Germán-Romero, Ana (Topics in Stroke Rehabilitation, 2020)
      Objective: To assess the effectiveness of Extracorporeal Shock Wave Therapy (ESWT) to reduce lower limb spasticity in adult stroke survivors. Data Sources: A systematic review of Medline/Pubmed, CENTRAL, ...

    • Assessment of the 4-meter walk test test-retest reliability and concurrent validity and its correlation with the five sit-to-stand test in chronic ambulatory stroke survivors 

      Cabanas-Valdés, Rosa; García-Rueda, Laura; Salgueiro, Carina; Albert, Pérez-Bellmunt; Rodríguez-Sanz, Jacobo; López-de-Celis, Carlos (Gait & Posture, 2023)
      Background: The 4-meter walk test (4-MWT) is a widely used measure to assess gait speed in the elderly but has not been validated for stroke survivors to date. Objectives: To assess the test-retest ...

    • Telerehabilitation for balance rehabilitation in the subacute stage of stroke: a pilot controlled trial 

      Salgueiro, Carina; Urrútia, Gerard; Cabanas-Valdés, Rosa (NeuroRehabilitation, 2022)
      BACKGROUND:Telerehabilitation has been proposed as an effective strategy to deliver post-stroke specific exercise. OBJECTIVE:To assess the effectiveness and feasibility of core stability exercises guided ...

    • Motor rehabilitation after stroke: European Stroke Organisation (ESO) consensus-based definition and guiding framework 

      Kwakkel, Gert; Stinear, Cathy; Essers, Bea; Munoz-Novoa, Maria; Branscheidt, Meret; Cabanas-Valdés, Rosa; Lakičević, Sandra; Lampropoulou, Sofia; Luft, Andreas R.; Marque, Philippe; Moore, Sarah A.; Solomon, John M.; Swinnen, Eva; Turolla, Andrea; Alt Murphy, Margit; Verheyden, Geert (European Stroke Journal, 2023)
      Purpose: To propose a consensus-based definition and framework for motor rehabilitation after stroke. Methods: An expert European working group reviewed the literature, attaining internal consensus after ...

    • Combined aerobic exercise and high-intensity respiratory muscle training in patients surgically treated for non-small cell lung cancer: a pilot randomized clinical trial 

      Messaggi-Sartor, Monique; Marco, Ester; Martínez-Téllez, Elisabeth; Rodriguez-Fuster, Alberto; Palomares, Carolina; Chiarella, Sandra; Muniesa, Josep M.; Orozco-Levi, Mauricio; Barreiro, Esther; Güell, Maria R (European Journal of Physical and Rehabilitation Medicine, 2019)
      BACKGROUND: Lung resection surgery further decreases exercise capacity and negatively affects respiratory muscle function in patients with non-small cell lung cancer (NSCLC). The best design for exercise ...

    • Prospective study of shoulder strength, shoulder range of motion, and lymphedema in breast cancer patients from pre-surgery to 5 years after ALND or SLNB 

      Belmonte, Roser; Messaggi-Sartor, Monique; Ferrer, Montse; Pont, Angels; Escalada, Ferran (Supportive Care in Cancer, 2018)
      Objective: Determine the changes in shoulder strength, shoulder range of motion, and arm volume in breast cancer patients treated with sentinel lymph node biopsy (SLNB) or axillary lymph node dissection ...

    • Respiratory muscle strength training and neuromuscular electrical stimulation in subacute dysphagic stroke patients: a randomized controlled trial 

      Guillén-Solà, Anna; Messagi Sartor, Monique; Bofill Soler, Neus; Duarte, Esther; Camelia Barrera, Mª; Marco, Ester (Clinical Rehabilitation, 2016)
      Objective: To evaluate the effectiveness of inspiratory/expiratory muscle training (IEMT) and neuromuscular electrical stimulation (NMES) to improve dysphagia in stroke. Design: Prospective, single-blind, ...

    • Inspiratory and expiratory muscle training in subacute stroke: a randomized clinical trial 

      Messaggi-Sartor, Monique; Guillen-Solà, Anna; Depolo, Marina; Duarte, Esther; Rodríguez, Diego A.; Barrera, Maria-Camelia; Barreiro, Esther; Escalada, Ferran; Orozco-Levi, Mauricio; Marco, Ester (Neurology, 2015)
      Objective: To assess the effectiveness, feasibility, and safety of short-term inspiratory and expiratory muscle training (IEMT) in subacute stroke patients. Methods: Within 2 weeks of stroke onset, 109 ...

    • High-intensity vs. sham inspiratory muscle training in patients with chronic heart failure: a prospective randomized trial 

      Marco, Ester; Ramírez-Sarmiento, Alba L; Coloma, Ana; Sartor, Monique; Comin-Colet, Josep; Vila, Joan; Enjuanes, Cristina; Bruguera, Jordi; Escalada, Ferran; Gea, Joaquim; Orozco-Levi, Mauricio (European Journal of Heart Failure, 2014)
      Aims: The purpose of this study was to evaluate the effectiveness, feasibility, and safety of a 4-week high-intensity inspiratory muscle training (hi-IMT) in patients with chronic heart failure (CHF). ...

    • Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype 

      Maus, Mate; López Polo, Vanessa; Mateo, Lidia; Lafarga, Miguel; Aguilera, Mònica; De Lama, Eugenia; Meyer, Kathleen; SOLA, ANNA; Lopez-Martinez, Cecilia; López-Alonso, Ines; Guasch-Piqueras, Marc; Hernandez-Gonzalez, Fernanda; Chaib, Selim; Rovira, Miguel; Sanchez-Fernandez, Mayka; Faner, Rosa; Agusti, Alvar; Diéguez-Hurtado, Rodrigo; Ortega, Sagrario; Manonelles, Anna; Engelhardt, Stefan; Monteiro, Freddy; Stephan-Otto Attolini, Camille; Prats, Neus; M. Albaiceta, Guillermo; CRUZADO, JOSEP M; Serrano, Manuel (Nature Metabolism, 2023)
      Fibrogenesis is part of a normal protective response to tissue injury that can become irreversible and progressive, leading to fatal diseases. Senescent cells are a main driver of fibrotic diseases ...

    • Protocol to quantify polyphosphate in human cell lines using a tagged PPBD peptide 

      Jiménez, Javier; Lázaro, Blanca; Sarrias, Ana; Tadeo, Francisco J.; Pérez-Montero, Marta; Clotet, Josep; Bru Rullo, Samuel (STAR Protocols, 2022)
      Polyphosphate (polyP) is an evolutionarily conserved polymer of phosphates that is difficult to study in human cells because of its low concentration and high lability. First, we described how to express ...

    • CDK-mediated Yku80 phosphorylation regulates the balance between non-homologous end joining (NHEJ) and homologous directed recombination (HDR) 

      Carballar, Reyes; Martínez-Láinez, Joan M.; Samper, Bàrbara; Bru, Samuel; Bállega, Elisabet; Mirallas, Oriol; Ricco, Natalia; Clotet, Josep; Jiménez, Javier (Journal of Molecular Biology, 2020)
      There are two major pathways for repairing DNA double-strand breaks (DSBs): homologous directed recombination (HDR) and non-homologous end-joining (NHEJ). While NHEJ functions throughout the cell cycle, ...

    • Determination of soluble angiotensin-converting enzyme 2 in saliva samples and its association with nicotine 

      Bru, Samuel; González-Marrón, Adrián; Lidón-Moyano, Cristina; Carballar, Reyes; Martínez-Lainez, Joan Marc; Pérez-Martín, Hipólito; Fu, Marcela; Pérez-Ortuno, Raúl; Ballbè, Montse; Pascual, Jose A.; Fernandez, Esteve; Clotet, Josep; Martínez-Sanchez, Jose M. (Environmental Research, 2023)
      Introduction: The Angiotensin-Converting Enzyme 2 (ACE2) is the main receptor of the SARS-CoV-2. There is contradictory evidence on how the exposure to nicotine may module the concentration of soluble ...

    • Exploring the link between MORF4L1 and risk of breast cancer 

      Martrat, Griselda; Maxwell, Christopher A.; Tominaga, Emiko; Porta-de-la-Riva, Montserrat; Bonifaci, Núria; Gómez-Baldó, Laia; Bogliolo, Massimo; Lázaro, Conxi; Blanco, Ignacio; Brunet, Joan; Aguilar, Helena; Fernández-Rodríguez, Juana; Seal, Sheila; Renwick, Anthony; Rahman, Nazneen; Kühl, Julia; Neveling, Kornelia; Schindler, Detlev; Ramírez, María J.; Castellà, María; Hernández, Gonzalo; EMBRACE; Easton, Douglas F.; Peock, Susan; Cook, Margaret; Oliver, Clare T.; Frost, Debra; Platte, Radka; Evans, D. Gareth; Lalloo, Fiona; Eeles, Rosalind; Izatt, Louise; Chu, Carol; Davidson, Rosemarie; Ong, Kai-Ren; Cook, Jackie; Douglas, Fiona; Hodgson, Shirley; Brewer, Carole; Morrison, Patrick J.; Porteous, Mary; Peterlongo, Paolo; Manoukian, Siranoush; Peissel, Bernard; Zaffaroni, Daniela; Roversi, Gaia; Barile, Monica; Viel, Alessandra; Pasini, Barbara; Ottini, Laura; Putignano, Anna Laura; Savarese, Antonella; Bernard, Loris; Radice, Paolo; Healey, Sue; Spurdle, Amanda; Chen, Xiaoqing; Beesley, Jonathan; kConFab; Rookus, Matti A.; Verhoef, Senno; Tilanus-Linthorst, Madeleine A.; Vreeswijk, Maaike P.; Asperen, Christi J.; Bodmer, Danielle; Ausems, Margreet GEM; Van Os, Theo A.; Blok, Marinus J.; Meijers-Heijboer, Hanne EJ; Hogervorst, Frans BL; HEBON; Goldgar, David E.; Buys, Saundra; John, Esther M.; Miron, Alexander; Southey, Melissa; Daly, Mary B.; BCFR; SWE-BRCA; Harbst, Katja; Borg, Åke; Rantala, Johanna; Barbany-Bustinza, Gisela; Ehrencrona, Hans; Stenmark-Askmalm, Marie; Kaufman, Bella; Laitman, Yael; Milgrom, Roni; Friedman, Eitan; Domchek, Susan M.; Nathanson, Katherine L.; Rebbeck, Timothy R.; Johannsson, Oskar Thor; Couch, Fergus J.; Wang, Xianshu; Fredericksen, Zachary; Cuadras, Daniel; Moreno, Víctor; Pientka, Friederike K.; Depping, Reinhard; Caldés, Trinidad; Osorio, Ana; Benítez, Javier; Bueren, Juan; Heikkinen, Tuomas; Nevanlinna, Heli; Hamann, Ute; Torres, Diana; Caligo, Maria Adelaide; Godwin, Andrew K.; Imyanitov, Evgeny N.; Janavicius, Ramunas; GEMO Study Collaborators; Sinilnikova, Olga M.; Stoppa-Lyonnet, Dominique; Mazoyer, Sylvie; Verny-Pierre, Carole; Castera, Laurent; De Pauw, Antoine; Bignon, Yves-Jean; Uhrhammer, Nancy; Peyrat, Jean-Philippe; Vennin, Philippe; Fert Ferrer, Sandra; Collonge-Rame, Marie-Agnès; Mortemousque, Isabelle; McGuffog, Lesley; Chenevix-Trench, Georgia; Pereira-Smith, Olivia M.; Antoniou, Antonis C.; Cerón, Julián; Tominaga, Kaoru; Surrallés, Jordi; Pujana, Miguel Angel (Breast Cancer Research, 2011)
      Introduction: Proteins encoded by Fanconi anemia (FA) and/or breast cancer (BrCa) susceptibility genes cooperate in a common DNA damage repair signaling pathway. To gain deeper insight into this pathway ...

    • Targeting DNA repair defects for precision medicine in prostate cancer 

      Athie, Alejandro; Arce-Gallego, Sara; Gonzalez, Macarena; Morales-Barrera, Rafael; Suarez, Cristina; Casals Galobart, Teresa; Hernandez Viedma, Gonzalo; Carles, Joan; Mateo, Joaquin (Current Oncology Reports, 2019)
      Purpose of Review: Genomic studies of localized and metastatic prostate cancer have identified a high prevalence of clinically actionable alterations including mutations in DNA repair genes. In this ...

    • Mutations in the RACGAP1 gene cause autosomal recessive congenital dyserythropoietic anemia type III 

      Hernández, Gonzalo; Romero-Cortadellas, Lídia; Ferrer-Cortès, Xènia; Venturi, Veronica; Dessy-Rodriguez, Mercedes; Olivella, Mireia; Husami, Ammar; Pérez De Soto, Concepción; Morales-Camacho, Rosario M.; Villegas, Ana; González-Fernández, Fernando-Ataulfo; Morado, Marta; Kalfa, Theodosia A.; Quintana-Bustamante, Oscar; Pérez-Montero, Santiago; Tornador, Cristian; Segovia, Jose-Carlos; Sánchez, Mayka (Haematologica, 2023)
      Congenital dyserythropoietic anemia type III (CDA III) is one of the rarest types of CDA. The autosomal dominant form of CDA III, is due to mono-allelic mutations in the KIF23 gene (MIM:105600); two ...

    • Control of systemic iron homeostasis by the 3’ iron-responsive element of divalent metal transporter 1 in mice 

      Tybl, Elisabeth; Gunshin, Hiromi; Gupta, Sanjay; Barrientos, Tomasa; Bonadonna, Michael; Celma Nos, Ferran; Palais, Gael; Karim, Zoubida; Sanchez, Mayka; Andrews, Nancy C.; Galy, Bruno (HemaSphere, 2020)
      Tight control of intestinal iron absorption is required to avoid both iron insufficiency and excess.1 Dietary nonheme iron is taken up by absorptive enterocytes via the apical iron transporter DMT1 ...

    • A mutation in the iron-responsive element of ALAS2 is a modifier of disease severity in a patient suffering from CLPX associated erythropoietic protoporphyria 

      Ducamp, Sarah; Luscieti, Sara; Ferrer-Cortès, Xènia; Nicolas, Gaël; Manceau, Hana; Peoc'h, Katell; Yien, Yvette Y.; Kannengiesser, Caroline; Gouya, Laurent; Puy, Herve; Sanchez, Mayka (Haematologica, 2021)
      Porphyrias are a group of eight genetically distinct disorders, each resulting from a partial deficiency or gain-offunction of a specific enzyme in the heme biosynthetic pathway.1 Porphyrias are inherited ...

    • The european hematology association roadmap for european hematology research: a consensus document 

      Engert, Andreas; Balduini, Carlo; Brand, Anneke; Coiffier, Bertrand; Cordonnier, Catherine; Döhner, Hartmut; Duyvené de Wit, Thom; Eichinger, Sabine; Fibbe, Willem; Green, Tony; De Haas, Fleur; Iolascon, Achille; Jaffredo, Thierry; Rodeghiero, Francesco; Salles, Gilles; Schuringa, Jan Jacob; EHA Roadmap for European Hematology Research, (Mayka Sanchez) (Haematologica, 2016)
      The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical ...

    • The actin binding protein profilin 2 is a novel regulator of iron homeostasis 

      Luscieti, Sara; Galy, Bruno; Gutierrez, Lucia; Reinke, Michael; Couso, Jorge; Shvartsman, Maya; Di Pascale, Antonio; Witke, Walter; Hentze, Matthias W.; Pilo Boyl, Pietro; Sanchez, Mayka (Blood, 2017)
      Cellular iron homeostasis is controlled by the iron regulatory proteins (IRPs) 1 and 2 that bind cis-regulatory iron-responsive elements (IRE) on target messenger RNAs (mRNA). We identified profilin 2 ...