Ciències de la Salut: Enviaments recents
Ara mostrant els elements 921-940 de 979
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Increased infammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice
(Scientific Reports, 2017-11-22)Obesity is associated with severe metabolic diseases such as type 2 diabetes, insulin resistance, cardiovascular disease and some forms of cancer. The pathophysiology of obesity-induced metabolic diseases ... -
Uridine 5'-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation
(PLoS One, 2014-06-06)In response to peripheral nerve injury, Schwann cells adopt a migratory phenotype and modify the extracellular matrix to make it permissive for cell migration and axonal re-growth. Uridine 5′-triphosphate ... -
Increasing Cervical Cancer Screening Coverage: A Randomised, Community-Based Clinical Trial
(PLoS One, 2017-01-24)Background: Opportunistic cervical cancer screening can lead to suboptimal screening coverage. Coverage could be increased after a personalised invitation to the target population. We present a community ... -
What attributes should be included in a discrete choice experiment related to health technologies? A systematic literature review
(PLoS One, 2019-07-18)Discrete choice experiments (DCEs) are a way to assess priority-setting in health care provision. This approach allows for the evaluation of individuals’ preferences as a means of adding criteria to ... -
Functional massage of the teres major muscle in patients with subacromial impingement syndrome: a randomized controlled case series study
(International Journal of Medical and Pharmaceutical Case Reports, 2016)Objective: the purpose of the present study was to analyze the concurrent validity and reliability of a force platform clinical COBS Feedback® for the estimation of the height of vertical jumps. Design: ... -
Validation of walking trails for the urban training of chronic obstructive pulmonary disease patients
(PLoS ONE, 2016-01-14)Purpose: Accessible interventions to train patients with chronic obstructive pulmonary disease (COPD) are needed. We designed urban trails of different intensities (low, moderate and high) in different ... -
Determinants of study completion and response to a 12-month behavioral physical activity intervention in chronic obstructive pulmonary disease: a cohort study
(PLoS ONE, 2019-05-20)Objectives: Physical activity is key to improve the prognosis of chronic obstructive pulmonary disease (COPD). To help to tailor future interventions we aimed to identify the baseline characteristics ... -
Alternatives to conventional hospitalization for improving lack of access to inpatient beds: a 12-year cross-sectional analysis
(Journal of Hospital Administration, 2013-12-17)Background/Objective: When hospitals cannot guarantee available hospital beds for inpatient admission, patients are exposed to prolonged waits, cancellations and diversions that negatively affect their ... -
Survival benefit of multidisciplinary care in amyotrophic lateral sclerosis in Spain: association with noninvasive mechanical ventilation
(Journal of Multidisciplinary Healthcare, 2019)Purpose: Multidisciplinary care has become the preferred model of care for patients with amyotrophic lateral sclerosis (ALS). It is assumed that the sum of interventions associated with this approach ... -
MMPs/TIMPs and inflammatory signalling de‐regulation in human incisional hernia tissues
(Journal of Cellular and Molecular Medicine, 2009-03-04)Incisional hernia is a common and important complication of laparotomies. Epidemiological studies allude to an underlying biological cause, at least in a subset of population. Interest has mainly focused ... -
Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12
(Cell Death and Disease, 2011-04-28)Disturbance of calcium homeostasis and accumulation of misfolded proteins in the endoplasmic reticulum (ER) are considered contributory components of cell death after ischemia. However, the signal-transducing ... -
In vivo osteogenic potential of biomimetic hydroxyapatite/collagen microspheres: comparison with injectable cement pastes
(PLoS One, 2015-07-01)The osteogenic capacity of biomimetic calcium deficient hydroxyapatite microspheres with and without collagen obtained by emulsification of a calcium phosphate cement paste has been evaluated in an in ... -
Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1
(eLife, 2019-09-13)Loss of proteostasis and cellular senescence are key hallmarks of aging, but direct cause-effect relationships are not well understood. We show that most yeast cells arrest in G1 before death with low ... -
Competition in the chaperone-client network subordinates cell-cycle entry to growth and stress
(Life Science Alliance, 2019-04-15)The precise coordination of growth and proliferation has a universal prevalence in cell homeostasis. As a prominent property, cell size is modulated by the coordination between these processes in ... -
Centromeric signaling proteins boost G1 cyclin degradation and modulate cell size in budding yeast
(PLoS Biology, 2018-08-06)Cell size scales with ploidy in a great range of eukaryotes, but the underlying mechanisms remain unknown. Using various orthogonal single-cell approaches, we show that cell size increases linearly ... -
Growth rate as a direct regulator of the start network to set cell size
(Frontiers in Cell and Developmental Biology, 2017-05-26)Cells are able to adjust their growth and size to external inputs to comply with specific fates and developmental programs. Molecular pathways controlling growth also have an enormous impact in cell ... -
Nucleosome architecture throughout the cell cycle
(Scientific Reports, 2016-01-28)Nucleosomes provide additional regulatory mechanisms to transcription and DNA replication by mediating the access of proteins to DNA. During the cell cycle chromatin undergoes several conformational ... -
The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation
(Nature Communications, 2012-08-21)Budding yeast cells are assumed to trigger Start and enter the cell cycle only after they attain a critical size set by external conditions. However, arguing against deterministic models of cell size ... -
The transcriptional network activated by Cln3 cyclin at the G1-to-S transition of the yeast cell cycle
(Genome Biology, 2010-06-23)Background: The G1-to-S transition of the cell cycle in the yeast Saccharomyces cerevisiae involves an extensive transcriptional program driven by transcription factors SBF (Swi4-Swi6) and MBF (Mbp1-Swi6). ... -
Polymeric additives to enhance the functional properties of calcium phosphate cements
(2012-03-20)The vast majority of materials used in bone tissue engineering and regenerative medicine are based on calcium phosphates due to their similarity with the mineral phase of natural bone. Among them, calcium ...