Evidence of functional declining and global comorbidity measured at baseline proved to be the strongest predictors for long-term death in elderly community residents aged 85 years: a 5-year follow-up evaluation, the OCTABAIX study
Author
Formiga, Francesc
Ferrer, Assumpta
Padros, Gloria
Montero, Abelardo
Gimenez-Argente, Carme
Corbella Virós, Xavier
Publication date
2016-04-18ISSN
1178-1998
Abstract
Objective: To investigate the predictive value of functional impairment, chronic conditions, and laboratory biomarkers of aging for predicting 5-year mortality in the elderly aged 85 years. Methods: Predictive value for mortality of different geriatric assessments carried out during the OCTABAIX study was evaluated after 5 years of follow-up in 328 subjects aged 85 years. Measurements included assessment of functional status comorbidity, along with laboratory tests on vitamin D, cholesterol, CD4/CD8 ratio, hemoglobin, and serum thyrotropin. Results: Overall, the mortality rate after 5 years of follow-up was 42.07%. Bivariate analysis showed that patients who survived were predominantly female (P=0.02), and they showed a significantly better baseline functional status for both basic (P<0.001) and instrumental (P<0.001) activities of daily living (Barthel and Lawton index), better cognitive performance (Spanish version of the Mini-Mental State Examination) (P<0.001), lower comorbidity conditions (Charlson) (P<0.001), lower nutritional risk (Mini Nutritional Assessment) (P<0.001), lower risk of falls (Tinetti gait scale) (P<0.001), less percentage of heart failure (P=0.03) and chronic obstructive pulmonary disease (P=0.03), and took less chronic prescription drugs (P=0.002) than nonsurvivors. Multivariate Cox regression analysis identified a decreased score in the Lawton index (hazard ratio 0.86, 95% confidence interval: 0.78–0.91) and higher comorbidity conditions (hazard ratio 1.20, 95% confidence interval: 1.08–1.33) as independent predictors of mortality at 5 years in the studied population. Conclusion: The ability to perform instrumental activities of daily living and the global comorbidity assessed at baseline were the predictors of death, identified in our 85-year-old community-dwelling subjects after 5 years of follow-up.
Document Type
Article
Document version
Accepted version
Language
English
Subject (CDU)
61 - Medical sciences
Keywords
Envelliment
Mortalitat
Comorbiditat
Envejecimiento
Mortalidad
Comorbilidad
Aging
Mortality
Comorbidity
Pages
8
Publisher
Dove Press
Collection
11;
Is part of
Clinical Interventions in Aging
Citation
Formiga, Francesc; Ferrer, Assumpta; Padros, Gloria [et al.]. Evidence of functional declining and global comorbidity measured at baseline proved to be the strongest predictors for long-term death in elderly community residents aged 85 years: a 5-year follow-up evaluation, the OCTABAIX study. Clinical Interventions in Aging, 2016, vol. 11, p. 437-444. Disponible en: <https://www.dovepress.com/evidence-of-functional-declining-and-global-comorbidity-measured-at-ba-peer-reviewed-article-CIA>. Fecha de acceso: 2 feb. 2020. DOI: 10.2147/CIA.S101447
This item appears in the following Collection(s)
- Ciències de la Salut [745]
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