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Related factors to streptococcus pneumoniae invasive infection and clinical manifestations: the potential role of nasopharyngeal microbiome
(Frontiers Media, 2021-04)
Infections of the lower respiratory tract, such as pneumonia, are one of the leading causes of death worldwide. Streptococcus pneumoniae might colonize the upper respiratory tract and is the main ...
Pneumococcal nasopharyngeal carriageamong Bhutanese children hospitalizedwith clinical pneumonia: serotypes andviral co-infection
(Springer Nature, 2020-12)
Background: Pneumococcal nasopharyngeal colonization (PNC) generally precedes pneumococcal disease. The purpose of this study was to determine the prevalence of PNC and to identify the pneumococcal ...
Rapid identification, capsular typing and molecular characterization of streptococcus pneumoniae by using whole genome nanopore sequencing
(Springer Nature, 2020)
Background: Whole genome sequencing has emerged as a useful tool for identification and molecular characterization of pathogens. MinION (Oxford Nanopore) is a real-time third generation sequencer whose ...
Changes in invasive pneumococcal disease caused by streptococcus pneumoniae serotype 1 following introduction of PCV10 and PCV13: findings from the PSERENADE project
(MDPI, 2021)
Streptococcus pneumoniae serotype 1 (ST1) was an important cause of invasive pneumococcal disease (IPD) globally before the introduction of pneumococcal conjugate vaccines (PCVs) containing ST1 antigen. ...
Genomic and serologic characterization ofenterovirus A71 brainstem encephalitis
(Wolters Kluwer, 2020)
Objective: In 2016, Catalonia experienced a pediatric brainstem encephalitis outbreak caused by enterovirus A71 (EV-A71). Conventional testing identified EV in the periphery but rarely in CSF. Metagenomic ...
Antibody conversion rates to SARS-CoV-2 in saliva from children attending summer schools in Barcelona, Spain
(Springer Nature, 2021)
Background: Surveillance tools to estimate viral transmission dynamics in young populations are essential to guide recommendations for school opening and management during viral epidemics. Ideally, ...
Differential nasopharyngeal microbiota composition in children according to respiratory health status
(Microbiology Society, 2021)
Acute respiratory infections (ARIs) constitute one of the leading causes of antibiotic administration, hospitalization and death among children <5 years old. The upper respiratory tract microbiota has ...
Pneumonia in children admitted to the national referral hospital in Bhutan: a prospective cohort study
(Elsevier, 2020-06)
Objectives: The study aim was to describe the etiological profile and clinical characteristics of pneumonia among children hospitalized in Thimphu, Bhutan. Methods: This prospective study enrolled ...
Association of clinical signs, host biomarkers and etiology with radiological pneumonia in bhutanese children
(Sage Journals, 2022)
Diagnosing pneumonia and identifying those requiring antibiotherapy remain challenging. Chest radiographs (CXR) are often used as the reference standard. We aimed to describe clinical characteristics, ...
Individual prevention and containment measures in schools in Catalonia, Spain, and community transmission of SARS-CoV-2 after school re-opening
(Public Library of Science, 2022)
Background: Despite their clear lesser vulnerability to COVID-19, the extent by which children are susceptible to getting infected by SARS-CoV-2 and their capacity to transmit the infection to other ...