Association of clinical signs, host biomarkers and etiology with radiological pneumonia in bhutanese children
Author
Jullien, Sophie
Richard-Greenblatt, Melissa
Casellas, Aina
Tshering, Kinley
Ribó, Jose Luis
Sharma, Ragunath
Tshering, Tashi
Pradhan, Dinesh
Dema, Kumbu
Ngai, Michelle
Kain, Kevin C.
Bassat, Quique
Publication date
2022ISSN
2333-794X
Abstract
Diagnosing pneumonia and identifying those requiring antibiotherapy remain challenging. Chest radiographs (CXR) are often used as the reference standard. We aimed to describe clinical characteristics, host-response biomarkers and etiology, and assess their relationship to CXR findings in children with pneumonia in Thimphu, Bhutan. Children between 2 and 59 months hospitalized with WHO-defined pneumonia were prospectively enrolled and classified into radiological endpoint and non-endpoint pneumonia. Blood and nasopharyngeal washing were collected for microbiological analyses and plasma levels of 11 host-response biomarkers were measured. Among 149 children with readable CXR, 39 (26.2%) presented with endpoint pneumonia. Identification of respiratory viruses was common, with no significant differences by radiological outcomes. No clinical sign was suggestive of radiological pneumonia, but children with radiological pneumonia presented higher erythrocyte sedimentation rate, C-reactive protein and procalcitonin. Markers of endothelial and immune activation had little accuracy for the reliable identification of radiological pneumonia.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
61 - Medical sciences
Keywords
Pneumònia
Nens
Bhutan
Radiografia
Marcadors inflamatoris
Neumonía
Niños
Bután
Radiografía
Marcadores inflamatorios
Pneumonia
Children
Bhutan
Radiography
Inflammatory markers
Pages
13
Publisher
Sage Journals
Collection
9;
Is part of
Global Pediatric Health
Citation
Jullien, Sophie; Richard-Greenblatt, Melissa; Casellas, Aina [et al.]. Association of clinical signs, host biomarkers and etiology with radiological pneumonia in bhutanese children. Global Pediatric Health, 2022, 9, p. 1-13. Disponible en: <https://journals.sagepub.com/doi/full/10.1177/2333794X221078698>. Fecha de acceso: 21 mar. 2022. DOI: 10.1177/2333794X221078698
This item appears in the following Collection(s)
- Ciències de la Salut [745]
Rights
Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc/4.0/