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Aberrantly spliced mRNAs of the 3-hydroxy-3-methylglutaryl coenzyme A lyase (HL) gene with a donor splice-site point mutation produce hereditary HL deficiency
(American Society for Biochemistry and Molecular Biology, 1996-11)
A novel point mutation in the 3-hydroxy-3methyl-glutaryl coenzyme A lyase gene was found in a Turkish patient with homozygous 3-hydroxy-3-methylglutaric acidemia. Amplification by RT-PCR of the mRNA ...
New insights of SF1 neurons in hypothalamic regulation of obesity and diabetes
(MDPI, 2021)
Despite the substantial role played by the hypothalamus in the regulation of energy balance and glucose homeostasis, the exact mechanisms and neuronal circuits underlying this regulation remain poorly ...
Effects of the manual therapy approach of segments C0-1 and C2-3 in the flexion-rotation test in patients with chronic neck pain: a randomized controlled trial
(MDPI, 2021-01)
Background: Flexion-rotation test predominantly measures rotation in C1-2 segment. Restriction in flexion-rotation may be due to direct limitation in C1-2, but also to a premature tightening of the alar ...
Conocimiento y uso de mecanismos de coordinación clínica de servicios de salud de Latinoamérica
(Elsevier, 2018)
Objetivo: Analizar el nivel de conocimiento y uso, y las características del uso, de los mecanismos de coordinación clínica entre niveles de atención en redes de servicios de salud de seis países de ...
Red blood cell distribution width as a prognostic factor of mortality in elderly patients firstly hospitalized due to heart failure
(Medycyna Praktyczna, 2019-04-29)
Background: Red blood cell distribution width (RDW) is a risk factor related to adverse outcome in patients with heart failure (HF). Less is known about its role in patients in their first hospitalization ...
Tirbanibulina: revisión de su mecanismo de acción novedoso y de cómo encaja en el tratamiento de la queratosis actínica
(Elsevier, 2021)
La queratosis actínica (QA) es una afección cutánea caracterizada por la proliferación de queratinocitos mutados que pueden convertirse en carcinoma escamoso cutáneo. Las terapias disponibles, aunque ...
SARS-CoV-2 transmission in teenagers and young adults in Fútbol Club Barcelona’s multidisciplinary sports training academy
(Elsevier, 2023)
Most studies, aimed at determining the incidence and transmission of SARS-CoV-2 in children and teenagers, have been developed in school settings. Our study conducted surveillance and inferred attack ...
Oscillation encoding of individual differences in speech perception
(Public Library of Science, 2014-07-03)
Individual differences in second language (L2) phoneme perception (within the normal population) have been related to speech perception abilities, also observed in the native language, in studies assessing ...
A truncated form of IKKa is responsible for specific nuclear IKK activity in colorectal cancer
(Elsevier, 2012-10-25)
Nuclear IKKα regulates gene transcription by phosphorylating specific substrates and has been linked to cancer progression and metastasis. However, the mechanistic connection between tumorigenesis and ...
The persistent breach between evidence and practice in the prevention of surgical site infection. Qualitative study
(Elsevier, 2020)
Background: Despite the dissemination of guidelines for surgical site infection (SSI) prevention, a gap between the theoretical measures and their compliance persists. Accurate estimates of the ...