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Modified shuttle test distance correlates with peak oxygen uptake in children and adolescents with severe therapy-resistant asthma
(Frontiers Media, 2019)
Introduction: Several tests may be used to assess exercise intolerance in severe therapy-resistant asthma (STRA), including the gold standard cardiopulmonary exercise test (CPET) and the modified shuttle ...
A systematic analysis of orphan cyclins reveals CNTD2 as a new oncogenic driver in lung cancer
(Scientific Reports, 2017-08-31)
As lung cancer has increased to the most common cause of cancer death worldwide, prognostic
biomarkers and efective targeted treatments remain lacking despite advances based on patients’
stratifcation. ...
Urban environment and physical activity and capacity in patients with chronic obstructive pulmonary disease
(Elsevier, 2022)
Background: Physical activity and exercise capacity are key prognostic factors in chronic obstructive pulmonary disease (COPD) but their environmental determinants are unknown. Objectives: To test the ...
Variation in nicotine metabolization according to biological factors and type of nicotine consumer
(MDPI, 2023)
This study aims to describe the nicotine metabolite ratio among tobacco smokers and electronic cigarette (e-cigarette) users and nonusers. We analyzed pooled data from a longitudinal and a cross-sectional ...
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
(Springer Nature, 2018)
With a diverse network of substrates, NUDIX hydrolases have emerged as a key family of nucleotide-metabolizing enzymes. NUDT5 (also called NUDIX5) has been implicated in ADP-ribose and 8-oxo-guanine ...
Fructose-1,6-bisphosphate prevents pulmonary fibrosis by regulating extracellular matrix deposition and inducing phenotype reversal of lung myofibroblasts
(Public Library of Science, 2019)
Pulmonary fibrosis (PF) is the result of chronic injury where fibroblasts become activated and secrete large amounts of extracellular matrix (ECM), leading to impaired fibroblasts degradation followed ...
Safety and efficacy of devices delivering Inhaled antibiotics among adults with non-cystic fibrosis bronchiectasis: a systematic review and a network meta-analysis
(MDPI, 2022)
It remains unknown whether the type of aerosol generating device is affecting efficacy and safety among non-cystic fibrosis bronchiectasis (NCFB) adults. The proposal of this network meta-analysis (NMA) ...
Related factors to streptococcus pneumoniae invasive infection and clinical manifestations: the potential role of nasopharyngeal microbiome
(Frontiers Media, 2021-04)
Infections of the lower respiratory tract, such as pneumonia, are one of the leading causes of death worldwide. Streptococcus pneumoniae might colonize the upper respiratory tract and is the main ...
Association of sleep disorders with heart rate variability in children and adolescents with cystic fibrosis
(Zeppelini Publishers, 2022)
Objective: To assess the association of sleep disorders with the findings of heart rate variability (HRV) in children and adolescents with cystic fibrosis (CF). Methods: Cross-sectional study including ...
A social return on investment analysis of improving the management of chronic obstructive pulmonary disease within the spanish national healthcare system
(Dove Press, 2022)
Purpose: To define a set of proposals that would improve the current management of chronic obstructive pulmonary disease (COPD) within the Spanish National Healthcare System (SNHS) from a comprehensive ...