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A truncated form of IKKa is responsible for specific nuclear IKK activity in colorectal cancer
(Elsevier, 2012-10-25)
Nuclear IKKα regulates gene transcription by phosphorylating specific substrates and has been linked to cancer progression and metastasis. However, the mechanistic connection between tumorigenesis and ...
Role of the NUDT enzymes in breast cancer
(MDPI, 2021)
Despite global research efforts, breast cancer remains the leading cause of cancer death in women worldwide. The majority of these deaths are due to metastasis occurring years after the initial treatment ...
Expression of oncogenic drivers in 3D cell culture depends on nuclear ATP synthesis by NUDT5
(MDPI, 2019)
The growth of cancer cells as oncospheres in three-dimensional (3D) culture provides a robust cell model for understanding cancer progression, as well as for early drug discovery and validation. We have ...