In vivo osteogenic potential of biomimetic hydroxyapatite/collagen microspheres: comparison with injectable cement pastes
Autor/a
Cuzmar, Erika
Pérez Antoñanzas, Roman
Manzanares-Céspedes, Maria Cristina
Ginebra Molins, Maria Pau
Franch, Jordi
Data de publicació
2015-07-01ISSN
1932-6203
Resum
The osteogenic capacity of biomimetic calcium deficient hydroxyapatite microspheres with and without collagen obtained by emulsification of a calcium phosphate cement paste has been evaluated in an in vivo model, and compared with an injectable calcium phosphate cement with the same composition. The materials were implanted into a 5 mm defect in the femur condyle of rabbits, and bone formation was assessed after 1 and 3 months. The histological analysis revealed that the cements presented cellular activity only in the margins of the material, whereas each one of the individual microspheres was covered with osteogenic cells. Consequently, bone ingrowth was enhanced by the microspheres, with a tenfold increase compared to the cement, which was associated to the higher accessibility for the cells provided by the macroporous network between the microspheres, and the larger surface area available for osteoconduction. No significant differences were found in terms of bone formation associated with the presence of collagen in the materials, although a more extensive erosion of the collagen-containing microspheres was observed.
Tipus de document
Article
Versió del document
Versió acceptada
Llengua
English
Matèries (CDU)
61 - Medicina
Paraules clau
Biomimetisme
Ossos--Creixement
Col·lagen
Histopatologia
Materials biomèdics
Biomimetics
Collagen diseases
Collagen--Structure
Bone development
Histology
Biomaterials
Biomateriales
Colágeno
Histología
Pàgines
15
Publicat per
Public Library of Science
Col·lecció
10; 7
Publicat a
PLoS One
Citació
Cuzmar, Erika; Perez, Roman A.; Manzanares, Maria-Cristina; Ginebra, Maria-Pau; Franch, Jordi. In vivo osteogenic potential of biomimetic hydroxyapatite/collagen microspheres: comparison with injectable cement pastes. PLos One, 2015, vol. 10, núm. 7, e0131188. Disponible en: <https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131188>- Fecha de acceso: 17 nov. 2019. DOI: 10.1371/journal.pone.0131188.
Número de l'acord de la subvenció
info:eu-repo/grantAgreement/ES/1PE/MAT2012-38438-C03
Aquest element apareix en la col·lecció o col·leccions següent(s)
- Ciències de la Salut [740]
Drets
© 2015 Cuzmar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited