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dc.contributor.authorCuzmar, Erika
dc.contributor.authorPérez Antoñanzas, Roman
dc.contributor.authorManzanares-Céspedes, Maria Cristina
dc.contributor.authorGinebra Molins, Maria Pau
dc.contributor.authorFranch, Jordi
dc.date.accessioned2019-11-17T16:41:36Z
dc.date.available2019-11-17T16:41:36Z
dc.date.issued2015-07-01
dc.identifier.citationCuzmar, Erika; Perez, Roman A.; Manzanares, Maria-Cristina; Ginebra, Maria-Pau; Franch, Jordi. In vivo osteogenic potential of biomimetic hydroxyapatite/collagen microspheres: comparison with injectable cement pastes. PLos One, 2015, vol. 10, núm. 7, e0131188. Disponible en: <https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131188>- Fecha de acceso: 17 nov. 2019. DOI: 10.1371/journal.pone.0131188.ca
dc.identifier.issn1932-6203ca
dc.identifier.urihttp://hdl.handle.net/20.500.12328/1331
dc.description.abstractThe osteogenic capacity of biomimetic calcium deficient hydroxyapatite microspheres with and without collagen obtained by emulsification of a calcium phosphate cement paste has been evaluated in an in vivo model, and compared with an injectable calcium phosphate cement with the same composition. The materials were implanted into a 5 mm defect in the femur condyle of rabbits, and bone formation was assessed after 1 and 3 months. The histological analysis revealed that the cements presented cellular activity only in the margins of the material, whereas each one of the individual microspheres was covered with osteogenic cells. Consequently, bone ingrowth was enhanced by the microspheres, with a tenfold increase compared to the cement, which was associated to the higher accessibility for the cells provided by the macroporous network between the microspheres, and the larger surface area available for osteoconduction. No significant differences were found in terms of bone formation associated with the presence of collagen in the materials, although a more extensive erosion of the collagen-containing microspheres was observed.ca
dc.format.extent15ca
dc.language.isoengca
dc.publisherPublic Library of Scienceca
dc.relation.ispartofPLoS Oneca
dc.relation.ispartofseries10;7
dc.rights© 2015 Cuzmar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedca
dc.subject.otherBiomimetismeca
dc.subject.otherOssos--Creixementca
dc.subject.otherCol·lagenca
dc.subject.otherHistopatologiaca
dc.subject.otherMaterials biomèdicsca
dc.subject.otherBiomimeticsca
dc.subject.otherCollagen diseasesca
dc.subject.otherCollagen--Structureca
dc.subject.otherBone developmentca
dc.subject.otherHistologyca
dc.subject.otherBiomaterialsca
dc.subject.otherBiomateriales
dc.subject.otherColágeno
dc.subject.otherHistología
dc.titleIn vivo osteogenic potential of biomimetic hydroxyapatite/collagen microspheres: comparison with injectable cement pastesca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/acceptedVersionca
dc.embargo.termscapca
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/1PE/MAT2012-38438-C03ca
dc.subject.udc61ca
dc.identifier.doihttps://dx.doi.org/10.1371/journal.pone.0131188ca


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