The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation
Autor/a
Ferrezuelo, Francisco
Colomina, Neus
Palmisano, Alida
Garí, Eloi
Gallego, Carme
Csikász-Nagy, Attila
Aldea Malo, Martí
Fecha de publicación
2012-08-21ISSN
2041-1723
Resumen
Budding yeast cells are assumed to trigger Start and enter the cell cycle only after they attain a critical size set by external conditions. However, arguing against deterministic models of cell size control, cell volume at Start displays great individual variability even under constant conditions. Here we show that cell size at Start is robustly set at a single-cell level by the volume growth rate in G1, which explains the observed variability. We find that this growth-rate-dependent sizer is intimately hardwired into the Start network and the Ydj1 chaperone is key for setting cell size as a function of the individual growth rate. Mathematical modelling and experimental data indicate that a growth-rate-dependent sizer is sufficient to ensure size homeostasis and, as a remarkable advantage over a rigid sizer mechanism, it reduces noise in G1 length and provides an immediate solution for size adaptation to external conditions at a population level.
Tipo de documento
Artículo
Versión del documento
Versión aceptada
Lengua
Inglés
Materias (CDU)
61 - Medicina
Palabras clave
Cèl·lules
Cells
Células
Cèl·lules--Creixement--Aspectes moleculars
Cells--Growth-Molecular aspects
Crecimiento celular
Homeòstasi
Homeostasis
Homeostasis
Páginas
11
Publicado por
Nature Research
Colección
3;
Publicado en
Nature Communications
Citación
Ferrezuelo, Francisco; Colomina, Neus; Palmisano, Alida; Garí, Eloi; Gallego, Carme; Csikász-Nagy, Attila; Aldea Malo, Martí. «The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation». Nature Communications, 2012, vol. 3, art. 1012. Disponible en: <https://www.nature.com/articles/ncomms2015>. Fecha de acceso: 21 oct. 2019. DOI: 10.1038/ncomms2015
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http://creativecommons.org/licenses/by-nc-nd/4.0/
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