The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation
Author
Ferrezuelo, Francisco
Colomina, Neus
Palmisano, Alida
Garí, Eloi
Gallego, Carme
Csikász-Nagy, Attila
Aldea Malo, Martí
Publication date
2012-08-21ISSN
2041-1723
Abstract
Budding yeast cells are assumed to trigger Start and enter the cell cycle only after they attain a critical size set by external conditions. However, arguing against deterministic models of cell size control, cell volume at Start displays great individual variability even under constant conditions. Here we show that cell size at Start is robustly set at a single-cell level by the volume growth rate in G1, which explains the observed variability. We find that this growth-rate-dependent sizer is intimately hardwired into the Start network and the Ydj1 chaperone is key for setting cell size as a function of the individual growth rate. Mathematical modelling and experimental data indicate that a growth-rate-dependent sizer is sufficient to ensure size homeostasis and, as a remarkable advantage over a rigid sizer mechanism, it reduces noise in G1 length and provides an immediate solution for size adaptation to external conditions at a population level.
Document Type
Article
Document version
Accepted version
Language
English
Subject (CDU)
61 - Medical sciences
Keywords
Cèl·lules
Cells
Células
Cèl·lules--Creixement--Aspectes moleculars
Cells--Growth-Molecular aspects
Crecimiento celular
Homeòstasi
Homeostasis
Homeostasis
Pages
11
Publisher
Nature Research
Collection
3;
Is part of
Nature Communications
Citation
Ferrezuelo, Francisco; Colomina, Neus; Palmisano, Alida; Garí, Eloi; Gallego, Carme; Csikász-Nagy, Attila; Aldea Malo, Martí. «The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation». Nature Communications, 2012, vol. 3, art. 1012. Disponible en: <https://www.nature.com/articles/ncomms2015>. Fecha de acceso: 21 oct. 2019. DOI: 10.1038/ncomms2015
This item appears in the following Collection(s)
- Ciències de la Salut [740]
Rights
http://creativecommons.org/licenses/by-nc-nd/4.0/
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-nd/4.0/