High effectiveness of a 14-day concomitant therapy for Helicobacter pylori treatment in primary care. An observational multicenter study
Autor/a
Olmedo, Llum
Azagra, Rafael
Aguyé, Amada
Pascual, Marta
Calvet, Xavier
Gené, Emili
Fecha de publicación
2020ISSN
2077-0383
Resumen
Background: The current cure rates with triple therapy combining a proton-pump inhibitor, amoxicillin and clarithromycin are unacceptably low. Aims: To evaluate the efficacy of a 14-day concomitant therapy as an empirical first-line treatment for curing Helicobacter pylori (Hp) infection in primary care. Methods: Patients from six primary care centers in Catalonia -Spain- were included consecutively. Hp status pre and post treatment was assessed according to local clinical practice protocol. A 14-day concomitant therapy (amoxicillin 1 g, clarithromycin 500 mg and metronidazole 500 mg plus omeprazole 20 mg, all drugs administered twice daily) was prescribed. Adherence to therapy and adverse events were assessed by personal interview. Results: 112 patients were enrolled. Mean age was 46.7 ± 16.1 years. Main indication for treatment was non-investigated dyspepsia (83%). Hp eradication was achieved in 100 of the 112 patients. Eradication rates were 89.3% (95% CI: 81.7–94.1) by intention-to-treat (ITT) analysis and 91.7% (95% CI; 84.6–95.9) per protocol (PP). No major side effects were reported; 104 (92.8%) patients complete the treatment. Forty-seven patients (42%) complained of mild side effects (metallic taste, nausea). Low adherence to treatment (p = 0.004) and significant adverse events (p = 0.004) were the variables associated with treatment failure. Conclusions: In primary care, a 14-day concomitant therapy is highly effective and well tolerated.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
English
Materias (CDU)
61 - Medicina
Palabras clave
Helicobacter
Eradicació
Tractament
Concomitant
Atenció primària
Multicèntric
Helicobacter
Erradicación
Tratamiento
Concomitante
Atención primaria
Multicéntrico
Helicobacter
Eradication
Treatment
Concomitant
Primary care
Multicenter
Páginas
8
Publicado por
MDPI
Colección
9; 8
Publicado en
Journal of Clinical Medicine
Citación
Olmedo, Llum; Azagra, Rafael; Aguyé, Amada [et al.]. High effectiveness of a 14-day concomitant therapy for Helicobacter pylori treatment in primary care. An observational multicenter study. Journal of Clinical Medicine, 2020, 9(8), 2410. Disponible en: <https://www.mdpi.com/2077-0383/9/8/2410>. Fecha de acceso: 8 feb. 2024. DOI: 10.3390/jcm9082410
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Derechos
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).